Results 201 to 210 of about 24,056 (240)

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

The organic cation transporters 1 and 2 mediate ethanolamine cellular efflux and control systemic phosphatidylethanolamine level. [PDF]

J Biol Chem
Schubert J, Koca F, Barone F, Corona G, Ciarimboli G, Visentin M.   +5 more
europepmc   +1 more source

Color-tunable luminescent Tb_xEu_y(BDC) complexes assembled within liposome-based nanoreactors.

Cell Rep Phys Sci
Torres-Huerta A, de J Velásquez-Hernández M, Lempereur S, Troian-Gautier L, Veronesi G, Valkenier H.   +5 more
europepmc   +1 more source

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Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions

Biochemical and Biophysical Research Communications, 2004
Organic cation transporter OCT1 (SLC22A1) plays an essential role in absorption, distribution, and excretion of various xenobiotics including therapeutically important drugs. In the present study, we analyzed the functional properties of the single nucleotide polymorphisms (SNPs) in SLC22A1 gene found in Japanese control individuals.
Naohiko Anzai, Yoshikatsu Kanai
exaly   +3 more sources

Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules

Pflügers Archiv - European Journal of Physiology, 2013
The proximal tubule of mouse kidney expresses mouse organic cation transporter 1 (mOCT1), mOCT2, and much less mOCT3. Therefore, mOCT-mediated transport across the basolateral membrane of proximal tubules reflects properties of at least mOCT1 and mOCT2.
Eberhard, Schlatter, Philipp, Klassen, Vivian, Massmann, Svenja K, Holle, Denise, Guckel, Bayram, Edemir, Hermann, Pavenstädt, Giuliano, Ciarimboli   +7 more
openaire   +2 more sources

The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances

2021
Organic cation transporters 1-3 (OCT1-3, SLC22A1-3) and the plasma membrane monoamine transporter (PMAT, SLC29A4) play a major role in maintaining monoaminergic equilibrium in the central nervous system. With many psychoactive substances interacting with OCT1-3 and PMAT, a growing literature focuses on characterizing their properties via in vitro and ...
Julian, Maier, Marco, Niello, Deborah, Rudin, Lynette C, Daws, Harald H, Sitte   +4 more
openaire   +2 more sources

Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin

The Journal of Pharmacology and Experimental Therapeutics, 2002
Metformin, a biguanide, is widely used as an oral hypoglycemic agent for the treatment of type 2 diabetes mellitus. The purpose of the present study was to investigate the role of organic cation transporter 1 (Oct1) in the disposition of metformin. Transfection of rat Oct1 cDNA results in the time-dependent and saturable uptake of metformin by the ...
Wang, DS, Jonker, JW, Kato, Y, Kusuhara, H, Schinkel, AH, Sugiyama, Y   +5 more
openaire   +3 more sources

Involvement of Organic Cation Transporter 1 in the Lactic Acidosis Caused by Metformin

Molecular Pharmacology, 2003
Biguanides are a class of drugs widely used as oral antihyperglycemic agents for the treatment of type 2 diabetes mellitus, but they are associated with lactic acidosis, a lethal side effect. We reported previously that biguanides are good substrates of rat organic cation transporter 1 (Oct1; Slc22a1) and, using Oct1(-/-) mice, that mouse Oct1 is ...
Wang, DS, Kusuhara, H, Kato, Y, Jonker, JW, Schinkel, AH, Sugiyama, Y   +5 more
openaire   +3 more sources

Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin

Naunyn-Schmiedeberg's Archives of Pharmacology, 2014
Flavonoids such as quercetin and kaempferol mediate several health protective effects, e.g., anticancer effects. They are inhibitors of organic anion transporting polypeptides (OATP) and organic cation transporters (e.g., OCT2). However, little is known whether such transporters contribute to the cellular uptake of flavonoids.
Hartmut, Glaeser, Krystyna, Bujok, Ingrid, Schmidt, Martin F, Fromm, Kathrin, Mandery   +4 more
openaire   +2 more sources

Extraneuronal Monoamine Transporter and Organic Cation Transporters 1 and 2: A Review of Transport Efficiency

2006
The extraneuronal monoamine transporter (EMT) corresponds to the classical steroid-sensitive monoamine transport mechanism that was first described as "uptake2" in rat heart with noradrenaline as substrate. The organic cation transporters OCT1 and OCT2 are related to EMT. The three carriers share basic structural and functional characteristics.
E, Schömig, A, Lazar, D, Gründemann
openaire   +2 more sources