Results 251 to 260 of about 55,182 (297)

Functional Characteristics and Tissue Distribution Pattern of Organic Cation Transporter 2 (OCTN2), an Organic Cation/Carnitine Transporter

The Journal of Pharmacology and Experimental Therapeutics, 1999
We have demonstrated in the present study that novel organic cation transporter (OCTN) 2 is a transporter for organic cations as well as carnitine. OCTN2 transports organic cations without involving Na(+), but it transports carnitine only in the presence of Na(+).
X, Wu, W, Huang, P D, Prasad, P, Seth, D P, Rajan, F H, Leibach, J, Chen, S J, Conway, V, Ganapathy   +8 more
openaire   +2 more sources

Interaction of green tea catechins with renal organic cation transporter 2

Xenobiotica, 2015
1. Green tea extract (GTE) and EGCG have previously shown to increase the uptake of MPP+ into Caco-2 cells. However, whether GTE and its derivatives interact with renal basolateral organic cation transporter 2 (Oct2) which plays a crucial role for cationic clearance remains unknown.
Chaliya, Jaiyen, Promsuk, Jutabha, Naohiko, Anzai, Anusorn, Lungkaphin, Sunhapas, Soodvilai, Chutima, Srimaroeng   +5 more
openaire   +2 more sources

Thiamine is a substrate of organic cation transporters in Caco-2 cells

European Journal of Pharmacology, 2012
The aim of this study was to characterize the intestinal absorption of thiamine, by investigating the hypothesis of an involvement of Organic Cation Transporter (OCT) family members in this process. [(3)H]-T(+) uptake was found to be: 1) time-dependent, 2) Na(+)- and Cl(-)-dependent, 3) pH-dependent, with uptake increasing with a decrease in ...
Clara Lemos, Ana Faria, Manuela Meireles, Fatima Martel, Rosario Monteiro, Conceicao Calhau   +5 more
openaire   +3 more sources

Characterization of regulatory mechanisms and states of human organic cation transporter 2

American Journal of Physiology-Cell Physiology, 2006
Polyspecific organic cation transporters (OCTs) have a large substrate binding pocket with different interaction domains. To determine whether OCT regulation is substrate specific, suitable fluorescent organic cations were selected by comparing their uptake in wild-type (WT) human embryonic kidney (HEK)-293 cells and in HEK-293 cells stably transfected
Biermann, Jürgen, Lang, Detlef, Gorboulev, Valentin, Koepsell, Hermann, Sindic, Aleksandra, Schröter, Rita, Zvirbliene, Aurelija, Pavenstädt, Hermann, Schlatter, Eberhard, Ciarimboli, Giuliano   +9 more
openaire   +4 more sources

Human organic cation transporter 2 (hOCT2): Inhibitor studies using S2-hOCT2 cells

Toxicology, 2013
Highly expressed in kidney and located on the basolateral membrane, human organic cation transporter 2 (hOCT2) can transport various compounds (i.e. drugs and toxins) into the proximal tubular cell. Using cultured proximal tubule cells stably expressing hOCT2 (i.e. S2-hOCT2 cells), we sought to probe different compound classes (e.g.
Shoetsu, Chiba, Toru, Ikawa, Hiroshi, Takeshita, Sanae, Kanno, Tomonori, Nagai, Meri, Takada, Toshiji, Mukai, Michael F, Wempe   +7 more
openaire   +2 more sources

Extraneuronal Monoamine Transporter and Organic Cation Transporters 1 and 2: A Review of Transport Efficiency

2006
The extraneuronal monoamine transporter (EMT) corresponds to the classical steroid-sensitive monoamine transport mechanism that was first described as "uptake2" in rat heart with noradrenaline as substrate. The organic cation transporters OCT1 and OCT2 are related to EMT. The three carriers share basic structural and functional characteristics.
E, Schömig, A, Lazar, D, Gründemann
openaire   +2 more sources

Basolateral localization of organic cation transporter 2 in intact renal proximal tubules

American Journal of Physiology-Renal Physiology, 2000
The localization of organic cation transporter 2 (OCT2) within renal cells is the subject of considerable controversy, resulting in marked uncertainty as to its function. To resolve this issue, we made an OCT2/green fluorescent protein (GFP) fusion construct (rOCT2-GFP) and determined its localization within Xenopus laevis oocytes and renal cells using
D H, Sweet, D S, Miller, J B, Pritchard
openaire   +2 more sources

Adenovirus stimulates choline efflux by increasing expression of organic cation transporter-2

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2005
We examined the effect of wild-type human adenovirus (Ad5) on choline transport in murine lung epithelia (MLE) and in rodent primary alveolar type II cells. Cells were active in pH-sensitive, reversible transport of choline, a process blocked pharmacologically with phenoxybenzamine, an inhibitor of organic cation transporters (OCT).
Olga L, Miakotina, Marianna, Agassandian, Lei, Shi, Dwight C, Look, Rama K, Mallampalli   +4 more
openaire   +2 more sources