Results 261 to 270 of about 55,182 (297)

Organic cation transporters 2: Structure, regulation, functions, and clinical implications

Drug Metabolism and Disposition
The SLC22A2 gene encodes organic cation transporter 2 (OCT2), which is predominantly expressed in renal proximal tubule cells. OCT2 is critical for the active renal excretion of various cationic drugs and endogenous metabolites. OCT2 expression varies across species, with higher levels in mice and monkeys compared with humans and rats.
Anoud, Ailabouni, Bhagwat, Prasad
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Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1)

Amino Acids, 2013
Asymmetric dimethylarginine (ADMA), inhibiting the nitric oxide (NO) synthesis from L-arginine, is a known cardiovascular risk factor. Our aim was to investigate if ADMA and/or L-arginine are substrates of the human cationic amino acid transporters 2A (CAT2A, SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the ...
Joachim, Strobel, Fabian, Müller, Oliver, Zolk, Beate, Endreß, Jörg, König, Martin F, Fromm, Renke, Maas   +6 more
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Neurochemical characterization of mouse dorsal root ganglion neurons expressing organic cation transporter 2

NeuroReport, 2020
Organic cation transporters (OCTs) are poly-specific carriers for endogenous and exogenous cationic compounds. These are widely distributed in the nervous system and mediate neuronal activities. As antineoplastic cationic drugs accumulate in the dorsal root ganglion (DRG), OCT function has been studied mainly in cultured DRG neurons.
Toshiyasu, Matsui, Takahiro, Nakata, Masamichi, Kurohmaru, Yasushi, Kobayashi   +3 more
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Organic Cation Transporters 2 as Mediators of Cisplatin Nephrotoxicity

2009
Cisplatin is an effective but highly nephrotoxic antineoplastic agent. Though many aspects of cisplatin interactions with DNA and cellular proteins are well described, specific systems for cisplatin transport across the cell membrane have only recently been identified. In this paper our findings on this topic are illustrated and reviewed in relation to
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Expression and localization of organic cation/carnitine transporter OCTN2 in Caco-2 cells

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2003
l-Carnitine is derived both from dietary sources and biosynthesis. Dietary carnitine is absorbed in the small intestine and then distributed to other organs. Previous studies using Caco-2 cells demonstrated that the transport ofl-carnitine in the intestine involves a carrier-mediated system. The purpose of this study was to determine whether the uptake
Ihsan, Elimrani, Karim, Lahjouji, Ernest, Seidman, Marie-Josee, Roy, Grant A, Mitchell, Ijaz, Qureshi   +5 more
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Novel Organic Cation Transporter 2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells

The Journal of Pharmacology and Experimental Therapeutics, 2005
The placental transport of carnitine is significant because the fetus cannot supply itself with adequate amounts of this nutrient. Carnitine deficiencies in infants can lead to symptoms ranging from muscle weakness to sudden infant death. Objectives of this study include the characterization of novel organic cation transporter 2 (OCTN2) function in the
Erik, Rytting, Kenneth L, Audus
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Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin

Clinical Pharmacology & Therapeutics, 2008
Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant differences in metformin pharmacokinetics when compared ...
I S, Song, H J, Shin, E J, Shim, I S, Jung, W Y, Kim, J H, Shon, J G, Shin   +6 more
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Identification of human-specific amino acid residues governing atenolol transport via organic cation transporter 2

Biochemical Pharmacology
Organic cation transporter 2 (OCT2/SLC22A2) is predominantly localized on the basolateral membranes of renal tubular epithelial cells and plays a crucial role in the renal secretion of various cationic drugs. Although variations in substrate selectivity among renal organic cation transport systems across species have been reported, the characteristics ...
Akira, Hosooka, Tomoya, Yasujima, Ayano, Murata, Takahiro, Yamashiro, Hiroaki, Yuasa   +4 more
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Involvement of Rat Organic Cation Transporter 2 in the Renal Uptake of Jatrorrhizine

Journal of Pharmaceutical Sciences, 2013
Jatrorrhizine is a protoberberine alkaloid derived from Coptis chinensis concentrated extremely in rat kidney. In the present study, the involvement of rat organic cation transporter 2 (rOCT2) in the renal uptake of jatrorrhizine in rat was investigated through in vitro and in vivo experiments.
Zhaodan, Tan, Rong, Zhu, Rong, Shi, Jie, Zhong, Yueming, Ma, Changhong, Wang, Xinhong, Wang, Nengneng, Cheng   +7 more
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Organic cation transporter 2 mRNA expression in dorsal root ganglia neurons

2010
Italian Journal of Anatomy and Embryology, Vol 115, No 1/2 (Supplement ...
CAVALETTI, GUIDO ANGELO, NICOLINI, GABRIELLA, CERESA, CECILIA, OGGIONI, NORBERTO, SALA, BARBARA, RIGOLIO, ROBERTA, CHIORAZZI, ALESSIA, TREDICI, GIOVANNI   +7 more
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