Results 101 to 110 of about 284,111 (305)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
, 2012 On most continents food production has surpassed the growth in population (Knudsen et al. 2006). Still it is estimated that approximately 1 billion people are undernourished (FAO 2011) and the greatest number of people suffering from chronic hunger are ...
Jacobsen, Malene
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FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Organization Oriented Chemical Computing [PDF]
, 2010 All known life forms process information on a bio-molecular level, which is known to be robust, self-organizing, adaptive, decentralized, asynchronous, fault tolerant, and evolvable. In order to exploit these properties it has been suggested to use artificial chemical systems like P-systems or artificial hormone systems.
openaire +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
, 2008 Paper presented at Agricultural and biosystems engineering for a sustainable world. International Conference on Agricultural Engineering, Hersonissos, Crete, Greece, 23-25 June, 2008Questions about the economic and environmental sustainability of current
Taffese Tanto, Mebrate, Magette, W. L.
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Understanding the causes of toxicity in treated landfill leachate through whole eefluent testing [PDF]
, 2010 Landfill leachate is collected and treated before discharge to protect the environment from a potential toxic cocktail of substances. In the U.K. biological treatment is the favourite technology for rendering landfill leachate safe due its simple ...
Thomas, David J. L.
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