Results 101 to 110 of about 400,616 (308)

Electrophilic fluorination at saturated carbon [PDF]

, 2000
Chapter 1 - Chapter 1 contains a discussion of the preparation and properties of elemental fluorine. A review of the use of elemental fluorine as a selective fluorinating in organic chemistry is given and the preparation and use of other selective ...
Parsons, Mandy
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Iron-based trinuclear metal-organic nanostructures on a surface with local charge accumulation

Nature Communications, 2018
Polynuclear metal-organic coordination complexes are often inaccessible by traditional synthetic chemistry methods. Here, the authors use on-surface supramolecular chemistry to form a planar trinuclear Fe complex, in which an accumulation of electrons ...
Cornelius Krull, Marina Castelli, Prokop Hapala, Dhaneesh Kumar, Anton Tadich, Martina Capsoni, Mark T. Edmonds, Jack Hellerstedt, Sarah A. Burke, Pavel Jelinek, Agustin Schiffrin   +10 more
doaj   +1 more source

Ashes for organic farming

, 2013
Nowadays only eight percent of the cultivated field area is used for organic farming. The Ministry of Agriculture and Forestry has published the guidelines for the program of organic farming to diversify the supply and the consumption of organic food ...
Peltonen, K., Suoniitty, T., Heinonen, M., Kousa, T.   +3 more
core  

Performance of the M062X density functional against the ISOL set of benchmark isomerization energies for large organic molecules

, 2010
Gas phase standard state (298.15 K, 1 atm) isomerization energies were calculated using the M062X functional with the QZVP, 6-311++G(d,p), 6-311++G(2d,2p), and cc-pVTZ basis sets against the 24 reactions in the ISOL set of benchmark isomerization ...
Sierra Rayne, Kaya Forest
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Chiral Selenium Electrophiles on Solid-Support

CHIMIA, 2001
Organoselenium chemistry has developed rapidly and selenium-based methods are now very useful in synthetic chemistry. The selective introduction of various functionalities into complex molecules can be accomplished under very mild reaction ...
Lars Uehlin, Thomas Wirth
doaj   +2 more sources

Anti-Orthopoxvirus Activity of Amantadine and Rimantadine Derivatives—In Vitro Testing and Molecular Modeling

Chemistry
In 2022, the number of mpox cases spiked worldwide, leading to a surge in scientific research on members of the Orthopoxvirus genus and the discovery of new compounds exhibiting anti-orthopoxvirus activity.
Ivan A. Moskalev, Ekaterina A. Akishina, Evgenij A. Dikusar, Olga I. Yarovaya, Sophia S. Borisevich, Edward M. Khamitov, Alexey Yu. Fedorov, Sergey G. Arkhipov, Nikolay I. Bormotov, Olga A. Serova, Larisa N. Shishkina, Vladimir. I. Potkin, Nariman F. Salakhutdinov   +12 more
doaj   +1 more source

Re-casting traditional organic experiments into green guided-inquiry based experiments: student perceptions

Green Chemistry Letters and Reviews, 2019
Green Chemistry principles can be used to re-cast traditional Organic chemistry experiments into more guided-inquiry based experiments. Inquiry questions related to green chemistry principles and metrics have been incorporated into our laboratory for the
Deborah Bromfield Lee
doaj   +1 more source

The Role of Analytical Chemistry in Agricultural Research: Main goals, Challenges, Demands

CHIMIA, 2002
Analytical chemistry has always played an important role in agricultural research, but its objectives and contributions have changed over time. In this paper a description of the historical development is given.
Hans Jörg Bachmann, Thomas Bucheli, Jean Paul, Hans Stünzi, Hans-Ruedi Bosshard   +4 more
doaj   +1 more source