Results 81 to 90 of about 15,831,855 (300)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Advanced organic chemistry : reaction mechanisms /

, 2002
A best-selling mechanistic organic chemistry text in Germany, this text's translation into English fills a long-existing need for a modern, thorough and accessible treatment of reaction mechanisms for students of organic chemistry at the advanced ...
Brückner, Reinhard
core  

Investigando cinza da casca do arroz como fase estacionária em cromatografia: uma proposta de aula experimental nos cursos de graduação

Química Nova, 2012
This article describes an experiment that involves the extraction and separation of the pigments of spinach extract by column chromatography using the silica obtained from rice husk ash as a stationary phase.
João R. de Freitas Filho, Jucleiton J. Rufino de Freitas, Ladjane Pereira da Silva, Juliano C. Rufino Freitas   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Lagrangian model of air-mass photochemistry and mixing using a trajectory ensemble: the Cambridge Tropospheric Trajectory model of Chemistry And Transport (CiTTyCAT) version 4.2 [PDF]

, 2011
A Lagrangian model of photochemistry and mixing is described (CiTTyCAT, stemming from the Cambridge Tropospheric Trajectory model of Chemistry And Transport), which is suitable for transport and chemistry studies throughout the troposphere. Over the last
Owen, M. S., M. Cain, E. Real, S. R. Arnold, Arnold, S. R., T. A. M. Pugh, Wild, O., Law, K. S., Pyle, J. A., Owen, S. M., A. R. MacKenzie, Hewitt, C. N., Arnold, S.R., Methven, J., J. A. Pyle, Emmerson, K. M., Emmerson, K.M., Law, K.S., Cain, Michelle, O. Wild, Owen, S.M., Pyle, J.A., K. S. Law, Cain, M., MacKenzie, A.R., K. M. Emmerson, S. M. Owen, C. N. Hewitt, Law, Kathy S., J. Methven, Pugh, T. A. M., Mackenzie, A. R., Real, Elsa, Hewitt, C.N., J. A . Pyle, Real, E., Mackenzie, Rob, Pugh, T.A.M., Pugh, Thomas, MacKenzie, A.R.; id_orcid   +39 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Organic Chemistry II

, 2010
Intermediate organic chemistry. Synthesis, structure determination, mechanism, and the relationships between structure and reactivity emphasized. Special topics in organic chemistry included to illustrate the role of organic chemistry in biological ...
Swager, Timothy Manning, Fu, Gregory C.
core  

Can agricultural cultivation methods influence the healthfulness of crops for foods [PDF]

, 2012
The aim of the current study was to investigate if there are any health effects of long-term consumption of organically grown crops using a rat model. Crops were retrieved over two years from along-term field trial at three different locations in Denmark ...
Lauridsen, Charlotte, Olesen, Jørgen E., Jørgensen, Henry, Jensen, Maja M., Halekoh, Ulrich   +4 more
core   +1 more source

Iron-based trinuclear metal-organic nanostructures on a surface with local charge accumulation

Nature Communications, 2018
Polynuclear metal-organic coordination complexes are often inaccessible by traditional synthetic chemistry methods. Here, the authors use on-surface supramolecular chemistry to form a planar trinuclear Fe complex, in which an accumulation of electrons ...
Cornelius Krull, Marina Castelli, Prokop Hapala, Dhaneesh Kumar, Anton Tadich, Martina Capsoni, Mark T. Edmonds, Jack Hellerstedt, Sarah A. Burke, Pavel Jelinek, Agustin Schiffrin   +10 more
doaj   +1 more source

The Role of Analytical Chemistry in Agricultural Research: Main goals, Challenges, Demands

CHIMIA, 2002
Analytical chemistry has always played an important role in agricultural research, but its objectives and contributions have changed over time. In this paper a description of the historical development is given.
Hans Jörg Bachmann, Thomas Bucheli, Jean Paul, Hans Stünzi, Hans-Ruedi Bosshard   +4 more
doaj   +1 more source