Results 61 to 70 of about 15,831,855 (300)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
N-Heterocyclic-Carbene-Catalyzed Domino Reactions via Two or More Activation Modes
iScience, 2018 Summary: Organocatalytic domino processes have become a rapidly growing area of research. N-heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts for various transformations and continue to have widespread application. In the last decade,
Xiang-Yu Chen +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Physical organic chemistry in the making [PDF]
, 1997 The discipline of physical organic chemistry will continue to occupy a central position in chemistry. The rapid increase in instrumentation and important theoretical developments allow the investigation of many problems of great complexity and challenge.
Engberts, J.B.F.N.
core +2 more sources
Development and validation of instruments to assess content knowledge and topic specific pedagogical content knowledge of teachers of organic chemistry [PDF]
, 2013 In 1986, Shulman described Pedagogical Content Knowledge (PCK), as the transformation of Content Knowledge into various forms which help students to understand the concepts.
Vokwana, Nonkanyiso Queen +1 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Vladimir Prelog i organska kemija u proteklom stoljeću [PDF]
Kemija u Industriji, 2007 Organic chemistry in the past century has undergone several profound changes and Vlado Prelog, as the great organic chemist of our time, was actively involved in these changes. During the first half of the 20th century, synthesis of new organic compounds
Sunko, D.
doaj
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Frontiers in ChemistryThe growing emphasis on sustainable development has propelled green chemistry into a vital framework for designing environmentally benign chemical processes.
Sayani Banerjee +4 more
doaj +1 more source