Results 71 to 80 of about 400,616 (308)

Organic Chemistry II

, 2003
Intermediate organic chemistry. Synthesis, structure determination, mechanism, and the relationships between structure and reactivity emphasized. Special topics in organic chemistry included to illustrate the role of organic chemistry in biological ...
Tabacco, Sarah A., Jamison, Timothy F.
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Organic Chemistry I

, 2012
Organic chemistry is the study of the carbon and the bonding patterns that make carbon the central element to life. A well-rounded science student must take courses in organic chemistry to understand its application to various other topics, such as the ...
The Saylor Foundation
core  

Novel chemistry of fluorinated carbanions [PDF]

, 1996
The research described within this thesis may be divided into four main subject areas: I. The amine fluoride TDAE(^2+)2F- (10) has been used as a useful soluble source of fluoride ion in both C-F and C-C bond forming reactions.
Gray, William K.
core  

Advancement of Actinide Metal-Organic Framework Chemistry via Synthesis of Pu-UiO-66

, 2020
We report the synthesis and characterization of the first plutonium metal-organic framework (MOF). Pu-UiO-66 expands the established UiO-66 series, which includes transition-metal, lanthanide, and early actinide elements in the hexanuclear nodes.
Ashley, Hastings, Debmalya, Ray, Omar K., Farha, Amy, Hixon, WooSeok, Jeong, Laura, Gagliardi   +5 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Revolutionizing organic synthesis through green chemistry: metal-free, bio-based, and microwave-assisted methods

Frontiers in Chemistry
The growing emphasis on sustainable development has propelled green chemistry into a vital framework for designing environmentally benign chemical processes.
Sayani Banerjee, Sakthi Periyasamy, Kathiravan Muthukumaradoss, Priya Deivasigamani, Venkatesan Saravanan   +4 more
doaj   +1 more source

Data retention in organic ferroelectric resistive switches

, 2016
Solution-processed organic ferroelectric resistive switches could become the long-missing non-volatile memory elements in organic electronic devices. To this end, data retention in these devices should be characterized, understood and controlled.
Gelinck, G., Janssen, Rene A. J.,, Khikhlovskyi, V., Khikhlovskyi, V Vsevolod, Kemerink, M Martijn, Breemen, A.J.J.M. van, Khikhlovskyi, Vsevolod, Kemerink, Martijn, van Breemen, Albert J. J. M., Gelinck, G.H., Gelinck, G Gerwin, Gelinck, Gerwin H.,, van Breemen, AJJM, Khikhlovskyi, Vsevolod,, Kemerink, Martijn,, Gelinck, Gerwin H., Janssen, RAJ René, Janssen, R.A.J.; id_orcid, Kemerink, M., Breemen, van, A.J.J.M., van Breemen, Albert J. J. M.,, Janssen, R.A.J., Janssen, Rene A. J.   +22 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Data-Driven Astrochemistry: One Step Further within the Origin of Life Puzzle

Life, 2018
Astrochemistry, meteoritics and chemical analytics represent a manifold scientific field, including various disciplines. In this review, clarifications on astrochemistry, comet chemistry, laboratory astrophysics and meteoritic research with respect to ...
Alexander Ruf, Louis L. S. d’Hendecourt, Philippe Schmitt-Kopplin   +2 more
doaj   +1 more source