Results 91 to 100 of about 15,831,855 (300)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Titania-promoted carboxylic acid alkylations of alkenes and cascade addition-cyclizations [PDF]

, 2014
Photochemical reactions employing TiO and carboxylic acids under dry anaerobic conditions led to several types of C-C bond-forming processes with electron-deficient alkenes.
Andrew Mills (1307034), Christopher O’Rourke (1307025), Miller, Philip, Miller, P., Phillip Miller, Phillip Miller (1307028), O'Rourke, C.; id_orcid, Andrew Mills, John C. Walton (15114), O'Rourke, C., Manley, David W, Miller, Phillip, Roy T. McBurney (1295667), Manley, D.W., Roy T. Mcburney, John C. Walton, David W. Manley, Mills, Andrew, McBurney, R. T., McBurney, R.T., Walton, John C, McBurney, Roy T, David W. Manley (1307031), Walton, J.C., Manley, D. W., O'Rourke, Christopher, Mills, A., Walton, J. C., Mills, A.; id_orcid   +28 more
core   +1 more source

Chiral Selenium Electrophiles on Solid-Support

CHIMIA, 2001
Organoselenium chemistry has developed rapidly and selenium-based methods are now very useful in synthetic chemistry. The selective introduction of various functionalities into complex molecules can be accomplished under very mild reaction ...
Lars Uehlin, Thomas Wirth
doaj   +2 more sources

Anti-Orthopoxvirus Activity of Amantadine and Rimantadine Derivatives—In Vitro Testing and Molecular Modeling

Chemistry
In 2022, the number of mpox cases spiked worldwide, leading to a surge in scientific research on members of the Orthopoxvirus genus and the discovery of new compounds exhibiting anti-orthopoxvirus activity.
Ivan A. Moskalev, Ekaterina A. Akishina, Evgenij A. Dikusar, Olga I. Yarovaya, Sophia S. Borisevich, Edward M. Khamitov, Alexey Yu. Fedorov, Sergey G. Arkhipov, Nikolay I. Bormotov, Olga A. Serova, Larisa N. Shishkina, Vladimir. I. Potkin, Nariman F. Salakhutdinov   +12 more
doaj   +1 more source

Re-casting traditional organic experiments into green guided-inquiry based experiments: student perceptions

Green Chemistry Letters and Reviews, 2019
Green Chemistry principles can be used to re-cast traditional Organic chemistry experiments into more guided-inquiry based experiments. Inquiry questions related to green chemistry principles and metrics have been incorporated into our laboratory for the
Deborah Bromfield Lee
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A convenient catalyst system for microwave accelerated cross-coupling of a range of aryl boronic acids with aryl chlorides [PDF]

, 2007
Article number 18A convenient microwave accelerated cross-coupling procedure between aryl chlorides with a range of boronic acids has been developed. An explanation for the low reactivity of highly fluorinated boronic acids in Suzuki coupling is provided.
Matthew L. Clarke, Marcia B. France, Edward J. Milton, Jose A. Fuentes, Clarke, Matthew L., France, Marcia B., Milton, Edward J., Fuentes, José A., Roff, Geoffrey J., Geoffrey J. Roff   +9 more
core   +1 more source

Porphyrin Dyes for Nonlinear Optical Imaging of Live Cells

iScience, 2018
Summary: Second harmonic generation (SHG)-based probes are useful for nonlinear optical imaging of biological structures, such as the plasma membrane.
Anjul Khadria, Jan Fleischhauer, Igor Boczarow, James D. Wilkinson, Michael M. Kohl, Harry L. Anderson   +5 more
doaj   +1 more source

Synthetic Methods of Organic Chemistry A Thesaurus [PDF]

Nature, 1948
This is a new type of organic chemical publication. The volume under review is a translation of a German version published in Basle in 1946, and purports to cover the original literature of the period 1942–44. In fact, references to earlier publications are frequently given. Volume 2, covering the literature of 1945–46, has now been published in German,
openaire   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source