Results 91 to 100 of about 1,136,862 (292)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Chiral Selenium Electrophiles on Solid-Support

CHIMIA, 2001
Organoselenium chemistry has developed rapidly and selenium-based methods are now very useful in synthetic chemistry. The selective introduction of various functionalities into complex molecules can be accomplished under very mild reaction ...
Lars Uehlin, Thomas Wirth
doaj   +2 more sources

Anti-Orthopoxvirus Activity of Amantadine and Rimantadine Derivatives—In Vitro Testing and Molecular Modeling

Chemistry
In 2022, the number of mpox cases spiked worldwide, leading to a surge in scientific research on members of the Orthopoxvirus genus and the discovery of new compounds exhibiting anti-orthopoxvirus activity.
Ivan A. Moskalev, Ekaterina A. Akishina, Evgenij A. Dikusar, Olga I. Yarovaya, Sophia S. Borisevich, Edward M. Khamitov, Alexey Yu. Fedorov, Sergey G. Arkhipov, Nikolay I. Bormotov, Olga A. Serova, Larisa N. Shishkina, Vladimir. I. Potkin, Nariman F. Salakhutdinov   +12 more
doaj   +1 more source

Re-casting traditional organic experiments into green guided-inquiry based experiments: student perceptions

Green Chemistry Letters and Reviews, 2019
Green Chemistry principles can be used to re-cast traditional Organic chemistry experiments into more guided-inquiry based experiments. Inquiry questions related to green chemistry principles and metrics have been incorporated into our laboratory for the
Deborah Bromfield Lee
doaj   +1 more source

The Role of Analytical Chemistry in Agricultural Research: Main goals, Challenges, Demands

CHIMIA, 2002
Analytical chemistry has always played an important role in agricultural research, but its objectives and contributions have changed over time. In this paper a description of the historical development is given.
Hans Jörg Bachmann, Thomas Bucheli, Jean Paul, Hans Stünzi, Hans-Ruedi Bosshard   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Review of Tropospheric Atmospheric Chemistry and Gas-Phase Chemical Mechanisms for Air Quality Modeling

Atmosphere, 2011
Gas-phase chemical mechanisms are vital components of prognostic air quality models. The mechanisms are incorporated into modules that are used to calculate the chemical sources and sinks of ozone and the precursors of particulates.
Wendy S. Goliff, William R. Stockwell, Emily Saunders, Charlene V. Lawson   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Photoredox Chemistry with Organic Catalysts: Role of Computational Methods

ACS Omega, 2021
Kareesa J. Kron, Andres Rodriguez-Katakura, Rachelle Elhessen, Shaama Mallikarjun Sharada   +3 more
doaj   +1 more source