Results 91 to 100 of about 400,616 (308)

Accounting for instream lakes when interpolating stream water chemistry observations [PDF]

, 2011
Direct monitoring of stream water chemistry is an increasingly important tool for securing stream water quality and assessing stream ecological functioning as it relates to overall ecosystem health.
Temnerud, Johan, Braun, Hendrik, Lyon, Steve W.   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Perfluoroalkylation of aromatic systems [PDF]

, 1997
I. We have concentrated on the synthesis of aromatic systems containing CH(_2)R(_F) groups, where R(_F) is a bulky group derived from hexafluoropropene dimer, using fluoride ion induced methodology.
Magron, Corinne
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Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Investigando cinza da casca do arroz como fase estacionária em cromatografia: uma proposta de aula experimental nos cursos de graduação

Química Nova, 2012
This article describes an experiment that involves the extraction and separation of the pigments of spinach extract by column chromatography using the silica obtained from rice husk ash as a stationary phase.
João R. de Freitas Filho, Jucleiton J. Rufino de Freitas, Ladjane Pereira da Silva, Juliano C. Rufino Freitas   +3 more
doaj   +1 more source

Organic Transformations on σ-Aryl Organometallic

, 2007
This work reviews recent developments in the field of organic transformations on σ-aryl organometallic complexes. The general notion that M-C bonds are kinetically labile, highly reactive, and incompatible with typical reaction conditions met in organic ...
Homogene katalyse en materialen, van Koten, G., Chemical Biology & Organic Chemistry, Chase, P.A., Klein Gebbink, R.J.M., Snelders, D.J.M., Dep Scheikunde, Gagliardo, M., van Klink, G.P.M.   +8 more
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Residual influence of organic materials, crop residues, and biofertilizers on performance of succeeding mung bean in an organic rice-based cropping system

, 2012
The present investigation was undertaken to assess the residual influence of organic materials and biofertilizers applied to rice and wheat on yield, nutrient status, and economics of succeeding mung bean in an organic cropping system.
Mohammad Mirzakhani, Shriniwas, Sharma, Mohammad, Mirzakhani, Shri Niwas Sharma, Mohammadreza Davari, Mohammadreza, Davari   +5 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Porphyrin Dyes for Nonlinear Optical Imaging of Live Cells

iScience, 2018
Summary: Second harmonic generation (SHG)-based probes are useful for nonlinear optical imaging of biological structures, such as the plasma membrane.
Anjul Khadria, Jan Fleischhauer, Igor Boczarow, James D. Wilkinson, Michael M. Kohl, Harry L. Anderson   +5 more
doaj   +1 more source

Computing the aqueous solubility of organic drug-like molecules and understanding hydrophobicity

, 2015
This thesis covers a range of methodologies to provide an account of the current (2010-2014) state of the art and to develop new methods for solubility prediction.
Mcdonagh, James, McDonagh, James L.
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