Results 111 to 120 of about 1,800,963 (373)

Iron-based trinuclear metal-organic nanostructures on a surface with local charge accumulation

Nature Communications, 2018
Polynuclear metal-organic coordination complexes are often inaccessible by traditional synthetic chemistry methods. Here, the authors use on-surface supramolecular chemistry to form a planar trinuclear Fe complex, in which an accumulation of electrons ...
Cornelius Krull, Marina Castelli, Prokop Hapala, Dhaneesh Kumar, Anton Tadich, Martina Capsoni, Mark T. Edmonds, Jack Hellerstedt, Sarah A. Burke, Pavel Jelinek, Agustin Schiffrin   +10 more
doaj   +1 more source

The Role of Analytical Chemistry in Agricultural Research: Main goals, Challenges, Demands

CHIMIA, 2002
Analytical chemistry has always played an important role in agricultural research, but its objectives and contributions have changed over time. In this paper a description of the historical development is given.
Hans Jörg Bachmann, Thomas Bucheli, Jean Paul, Hans Stünzi, Hans-Ruedi Bosshard   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Chiral Selenium Electrophiles on Solid-Support

CHIMIA, 2001
Organoselenium chemistry has developed rapidly and selenium-based methods are now very useful in synthetic chemistry. The selective introduction of various functionalities into complex molecules can be accomplished under very mild reaction ...
Lars Uehlin, Thomas Wirth
doaj   +2 more sources

Anti-Orthopoxvirus Activity of Amantadine and Rimantadine Derivatives—In Vitro Testing and Molecular Modeling

Chemistry
In 2022, the number of mpox cases spiked worldwide, leading to a surge in scientific research on members of the Orthopoxvirus genus and the discovery of new compounds exhibiting anti-orthopoxvirus activity.
Ivan A. Moskalev, Ekaterina A. Akishina, Evgenij A. Dikusar, Olga I. Yarovaya, Sophia S. Borisevich, Edward M. Khamitov, Alexey Yu. Fedorov, Sergey G. Arkhipov, Nikolay I. Bormotov, Olga A. Serova, Larisa N. Shishkina, Vladimir. I. Potkin, Nariman F. Salakhutdinov   +12 more
doaj   +1 more source

Re-casting traditional organic experiments into green guided-inquiry based experiments: student perceptions

Green Chemistry Letters and Reviews, 2019
Green Chemistry principles can be used to re-cast traditional Organic chemistry experiments into more guided-inquiry based experiments. Inquiry questions related to green chemistry principles and metrics have been incorporated into our laboratory for the
Deborah Bromfield Lee
doaj   +1 more source

Models of wave-function collapse, underlying theories, and experimental tests

, 2012
We describe the state of the art in preparing, manipulating and detecting coherent molecular matter. We focus on experimental methods for handling the quantum motion of compound systems from diatomic molecules to clusters or biomolecules.Molecular ...
Adler, S. L., Albert, D., Allen, L., Angelo Bassi, Arndt, M., Ashkin, A., Bell, J. S., Bell, J. S., Bell, J. S., Bohm, D., Breuer, H.-P., Bub, J., Christian, J., Deutsch, D., DeWitt, D. S., Dürr, D., Dürr, D., Feynman, R. P., Frenkel, A., Frenkel, A., Frenkel, A., Ghirardi, G., Ghirardi, G. C., Gikhman, I. I., Gisin, N., Goldin, G. A., Griffiths, R. B., Grishchuk, L. P., Hendrik Ulbricht, Holland, P. R., Joos, E., Karolyhazy, F., Karolyhazy, F., Karolyhazy, F., Karolyhazy, F., Karolyhazy, F., Kinjalk Lochan, Landau, L. D., Lyth, D. H., Maudlin, T., Myrvold, W. C., Omnès, R., Omnès, R., Pearle, P., Pearle, P., Pearle, P., Percival, I. C., Rauch, H., Schilpp, P. A., Schlosshauer, M., Seema Satin, Singh, T. P., Tejinder P. Singh, von Neumann, J., Wheeler, J. A.   +54 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source