Results 41 to 50 of about 43,041 (266)

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

Threat of Human Pathogens in Farmlands: A One Health Perspective

Journal of Sustainable Agriculture and Environment
A key aspect of “One Health” is to recognize that environmental health and human health are inseparable. In this interconnected network, farmland plays a crucial role, as it serves as a link connecting various ecosystems.
Gaofei Jiang, Xinrun Yang, Thomas Pommier, Yangchun Xu, Qirong Shen, Zhong Wei   +5 more
doaj   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Pseudomonas sp. CD1-mediated fermentation valorization of steviol glycoside production waste liquor and construction of a plant growth-promoting salt-tolerant formulation

Industrial Crops and Products
Steviol glycoside production waste liquor (STE), a byproduct enriched in soluble stevia polysaccharides, was used here as a substrate for microbial fermentation to generate a bioactive formulation.
Zhiyi Zhu, Peigen Li, Xue Han, Simin Liu, Runze Hu, Yujie Zhao, Yujie Shi, Xinjuan Xu, Tianjie Yang, Yangchun Xu, Caixia Dong, Qirong Shen   +11 more
doaj   +1 more source

Biochar, Organic Fertilizer, and Bio-Organic Fertilizer Improve Soil Fertility and Tea Quality

Agronomy
Tea, the world’s second most traded commodity, significantly impacts the economies of producing countries. However, prolonged cultivation leads to soil degradation, particularly through acidification and the depletion of essential nutrients, which adversely affects tea quality.
Rongxiu Yin, Lulu Li, Huifang Liu, Jianmei Yao, Chiyu Ma, Lulu Pu, Zhiwei Lei   +6 more
openaire   +2 more sources

A Global Methane Observation System to Reduce Uncertainty for Anthropogenic and Natural Sources and Sinks for Detecting and Attributing Climate Feedbacks

Advanced Science, EarlyView.
Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais, S. Peng, J. Chang, F. Li, Q. Zhu, K. Yuan, G. Hugelius, H. Li, Y. Cai, F. Chevallier, K. Tibrewal, E. A. Kort, K. Arndt, J. Watts, B. Buma, N. Besic, P. I. Palmer, H. Cadillo‐Quiroz, E. Euskirchen, M. J. Gondwe, A. Hoyt, R. Jackson, S. Malone, D. Monteverde, S. Natali, M. Ramonet, C. Rey‐Sanchez, L. B. Sagang, E. A. G. Schuur, R. Vargas, R. Varner, Z. Zhang, B. Poulter   +32 more
wiley   +1 more source

Exploring Regional Biogeography of Abundant and Rare Bacteria in Soils With Long‐Read CycloneSEQ

Journal of Sustainable Agriculture and Environment
Background Rare microbial communities represent an important component of biodiversity in soil ecosystems, co‐existing with abundant species to drive ecosystem multifunctionality and maintain its stable operation.
Yarong Li, Jiabao Yu, Yang Gao, Xinrun Yang, Yi Han, Yi Gao, Tianjie Yang, Xiaofang Wang, Yu Shi, Qirong Shen, Gaofei Jiang, Zhong Wei, Yangchun Xu   +12 more
doaj   +1 more source

Functional Study of Different Lignocellulases from Trichoderma guizhouence NJAU4742 in the Synergistic Degradation of Natural Straw

Fermentation
The enzyme-based degradation of lignocellulose for bioenergy production is an eco-friendly and sustainable approach. This study aimed to elucidate the enzymatic characteristics of endoglucanase (EGL), β-glucosidase (BGL), and xylanase (XYN) from ...
Tuo Li, Ronghua Pei, Jiaguo Wang, Yihao Zhou, Dongyang Liu   +4 more
doaj   +1 more source

Effect of CBM1 and linker region on enzymatic properties of a novel thermostable dimeric GH10 xylanase (Xyn10A) from filamentous fungus Aspergillus fumigatus Z5

AMB Express, 2018
Xylanase with a high thermostability will satisfy the needs of raising the temperature of hydrolysis to improve the rheology of the broth in industry of biomass conversion.
Youzhi Miao, Yanqiong Kong, Pan Li, Guangqi Li, Dongyang Liu, Qirong Shen, Ruifu Zhang   +6 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source