Results 71 to 80 of about 32,088 (265)
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
The turnover of organic matter in soil [PDF]
There is little quantitative data on the turnover of soil organic matter even for parts of the world where long-term field experiments have been carried out. Comparisons of turnover under different climatic conditions, under different systems of agriculture, under different plant associations, at different pH's, in soils differing mechanical ...
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Survey of Chemical Quality and Fertilizer Value of Vermicomposted Municipal Wastewater Sludge [PDF]
Using of organic waste resources especially municipal wastewater sludges for improvement of agricultural soils’ fertility is increasing , but in order to decrease environmental and health risks sludge must be stabilized before using in farms.
Abdolrahim Parvaresh +2 more
doaj
China organic-rich shale geologic features and special shale gas production issues
The depositional environment of organic-rich shale and the related tectonic evolution in China are rather different from those in North America. In China, organic-rich shale is not only deposited in marine environment, but also in non-marine environment:
Yiwen Ju +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
PENGARUH BAHAN ORGANIK TERHADAP POPULASI Aspergillus flavus PADA BEBERAPA JENIS TANAH [PDF]
The objective of the research was to study the effect of soil type and organic matters applied on the growth of innoculated Aspergillus flavus. Considering the caracteristics of soil and organic matter source types, the organic carbon content total ...
Sudadi, Endang Setyorini
doaj

