Results 81 to 90 of about 602,894 (266)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Journal of Agriculture and Environment for International DevelopmentMicrobial communities play an important role in plant functioning and development. The microbial population structure in the rhizosphere of six onion genotypes CRB, OPNB, CRR, OPNR, CRJ and OPNJ was monitored at three sampling times using the soil ...
Rania Aydi Ben Abdallah +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Journal of Agriculture and Rural Development in the Tropics and Subtropics, 2013 Urban and peri-urban agriculture (UPA) contributes to food security, serves as an opportunity for income generation, and provides recreational services to urban citizens. With a population of 21 Million people, of which 60 % live in slums, UPA activities
Prem Jose Vazhacharickal +4 more
doaj
Discover FoodFor centuries, apricots (Prunus armeniaca L.) were used as a staple food in Gilgit-Baltistan (G-B), northern Pakistan where their high nutritional and medicinal value is still highly appreciated by many inhabitants.
Iftikhar Alam +6 more
doaj +1 more source
Performance Evaluation of Two Slow-Medium Growing Chicken Strains Maintained under Organic Production System during Different Seasons. [PDF]
Animals (Basel), 2021 Sarmiento-García A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Geo: Geography and EnvironmentLittle is known about the complex power and governance dynamics within e‐waste hubs in the Global South. Taking the example of Sodom‐Agbogbloshie, Mortuary‐road, Ashaiman and Ashaiman New Town in Ghana's capital Accra, we explore their role as catalysts ...
Khiddir Iddris +4 more
doaj +1 more source
Differences in Processing Quality Traits, Protein Content and Composition between Spelt and Bread Wheat Genotypes Grown under Conventional and Organic Production. [PDF]
Foods, 2021 Takač V +5 more
europepmc +1 more source