Results 21 to 30 of about 6,198,113 (423)

Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production

Scientific Reports, 2020
The development of targeted drugs for the treatment of cancer remains an unmet medical need. This study was designed to investigate the mechanism underlying breast cancer cell growth suppression caused by fused isoselenazolium salts.
Marina Makrecka-Kuka, Pavels Dimitrijevs, Ilona Domracheva, Kristaps Jaudzems, Maija Dambrova, Pavel Arsenyan   +5 more
doaj   +1 more source

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury

Physiological Reports, 2020
Many drug candidates have shown significant renoprotective effects in preclinical models; however, there is no clinically used effective pharmacotherapy for acute kidney injury.
Reinis Vilskersts, Karlis Vilks, Melita Videja, Helena Cirule, Olga Zharkova‐Malkova, Eduards Sevostjanovs, Maija Dambrova, Edgars Liepinsh   +7 more
doaj   +1 more source

May 1,2-Dithiolane-4-carboxylic Acid and Its Derivatives Serve as a Specific Thioredoxin Reductase 1 Inhibitor?

Molecules, 2023
Thioredoxin reductase is an essential enzyme that plays a crucial role in maintaining cellular redox homeostasis by catalyzing the reduction of thioredoxin, which is involved in several vital cellular processes.
Anna Nikitjuka, Kristaps Krims-Davis, Iveta Kaņepe-Lapsa, Melita Ozola, Raivis Žalubovskis   +4 more
doaj   +1 more source

Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults

Physiological Reports, 2020
Aim Exercise training induces adaptations in muscle and other tissue mitochondrial metabolism, dynamics, and oxidative phosphorylation capacity. Mitochondrial fatty acid oxidation was shown to be pivotal for the anti‐inflammatory status of immune cells ...
Edgars Liepinsh, Elina Makarova, Liga Plakane, Ilze Konrade, Kaspars Liepins, Melita Videja, Eduards Sevostjanovs, Solveiga Grinberga, Marina Makrecka‐Kuka, Maija Dambrova   +9 more
doaj   +1 more source

Monte Carlo Simulation of Sugar Synthesis on Icy Dust Particles Intermittently Irradiated by UV in a Protoplanetary Disk [PDF]

A&A 662, A76 (2022), 2022
Context. While synthesis of organic molecules in molecular clouds or protoplanetary disks is complex, observations of interstellar grains, analyses of carbonaceous chondrites, and UV photochemistry experiments are rapidly developing and providing constraints on and clues to the complex organic molecule synthesis in space. It motivates us to construct a
arxiv   +1 more source

Epihalohydrins in Organic Synthesis [PDF]

Chemical Reviews, 2012
AbstractReview: 457 refs.
Matthias D'hooghe, Norbert De Kimpe, Girija S. Singh, Karen Mollet   +3 more
openaire   +4 more sources

Tailoring FPOX enzymes for enhanced stability and expanded substrate recognition

Scientific Reports, 2023
Fructosyl peptide oxidases (FPOX) are deglycating enzymes that find application as key enzymatic components in diabetes monitoring devices. Indeed, their use with blood samples can provide a measurement of the concentration of glycated hemoglobin and ...
Hajar Estiri, Shapla Bhattacharya, Jhon Alexander Rodriguez Buitrago, Rossella Castagna, Linda Legzdiņa, Giorgia Casucci, Andrea Ricci, Emilio Parisini, Alfonso Gautieri   +8 more
doaj   +1 more source

Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis.

Chemical Reviews, 2013
A fundamental aim in the field of catalysis is the development of new modes of small molecule activation. One approach toward the catalytic activation of organic molecules that has received much attention recently is visible light photoredox catalysis ...
Christopher K. Prier, D. A. Rankic, D. MacMillan   +2 more
semanticscholar   +1 more source

Improved method for the obtaining DTTA-appended 2,2’-bipyridine ligands for lanthanide cations

Chimica Techno Acta, 2022
The composition of the reaction mixture after DTTA tert-butyl ester alkylation with 6'-halomethyl-5-phenyl-2,2'-bipyridines was studied. In addition to the target product, DTTA-appended 2,2’-bipyridine, the corresponding 6'-hydroxymethyl-substituted 2,2’-
Dmitry S. Kopchuk, Alexey P. Krinochkin, Мaria I. Valieva, Еkaterina S. Starnovskaya, Yaroslav K. Shtaitz, Svetlana S. Rybakova, Evgeny D. Ladin, Ekaterina A. Kudryashova, Elvira R. Sharafieva, Оleg N. Chupakhin   +9 more
doaj   +1 more source

1,1′-{[3,5-Bis((dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis[4-(anthracen-9-yl)pyridin-1-ium] Dibromide

Molbank, 2022
A synthesis of a cationic moiety and fluorescent moieties containing amphiphilic 1,4-dihydropyridine (1,4-DHP) derivatives was performed starting with the Hantzsch-type cyclization of dodecyl acetoacetate, phenylaldehyde and ammonium acetate. Bromination
Reinis Ozolins, Mara Plotniece, Karlis Pajuste, Reinis Putralis, Nadiia Pikun, Arkadij Sobolev, Aiva Plotniece, Martins Rucins   +7 more
doaj   +1 more source