Results 41 to 50 of about 848 (256)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
The Organization of the Organization [PDF]
, 2020 Duane P. Schultz, Sydney Ellen Schultz
+5 more sources
Ecological imperatives in contemporary Hungarian poetry
Hungarian Studies Yearbook, 2023 The study reviews from an ecopoetic point of view the tendencies in Hungarian poetry of recent years that emphasise the biopoetic aspects of existence. László Lázár Lövétei’s eclogues, for example, renew the discourse from the perspective of the ancient ...
Csehy Zoltán
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Frontal lobe meningioma presenting as mania
Archives of Mental Health, 2017 Frontal meningiomas may present with psychological symptoms without any neurological signs. Diagnosis of frontal lobe tumours are often delayed due to the insidious nature of the symptoms and psychiatric symptoms being the initial presentation rather ...
S Mithun, Divya Hegde, Priya Sreedaran
doaj
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
IN SEARCH OF RELIABLE KNOWLEDGE: REFLECTION IN THE LIGHT OF THE THINKING OF JOHN ZIMAN
Cogitare Enfermagem, 2011 A reflective study, based on content analysis, which aimed to widen discussion among Nursing researchers on the subject of the challenges of scientific literature production, to attain a degree of knowledge which is reliable or nearly so, in the light of
Elizabeth Teixeira +1 more
doaj +1 more source