Results 61 to 70 of about 313,818 (219)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Centraliser pour décentraliser
Revue Internationale d’Éducation de Sèvres, 2003 In recent decades, the Argentinean education system has focused on redistributing responsibility and authority at national and federal levels. The education ministry has relinquished its service provision responsibilities in order to assert its role in ...
Iñes Aguerrondo
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Management - Factor of Organisation’s Competitiveness [PDF]
Robotica & Management, 2019 It is known that human resources are important in any organisation, and management is the element that has a determining role within it. This paper aims to highlight the role of the manager in the organisation and to increase its competitiveness.
Diana Tănase, Adrian Tănase
doaj
Les organisations sportives communistes de France (1923-2015)
Cahiers d’histoire, 2017 La trace historique laissée jusqu’à aujourd’hui par les organisations sportives communistes nationales peut s’apprécier au travers des militantismes sportifs, éducatifs et politiques premiers promus au cours du temps, en prenant soin d’en discerner les ...
Fabien Sabatier
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
L’organisation comme effet de médiation : Redéfinir le lien entre organisation et communication
CommuniquerComment expliquer un phénomène aussi général et aussi central que l’organisation sociale ? Telle est la question abordée dans cet article. Partant de l’analyse de l’énonciation, et plus généralement de la communication, celui-ci tente de démontrer la ...
François Cooren, James R. Taylor
doaj +1 more source