Results 151 to 160 of about 104,442 (306)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

GLÄDJE – är det samma för alla? En studie om värdeord och värderingar

, 2017
Syftet med studien var att beskriva och analysera ledningens och medarbetarnas syn på värderingsfrågor och företagskulturen i en större organisation. Vi ville undersöka hur väl ledningsgruppens syn överensstämmer med medarbetarnas, studien utgår alltså ...
Adolfsson, Karin, Fredling, Helena
core  

German version of the index of professional nursing governance: translation, cultural adaptation and psychometric validation. [PDF]

J Res Nurs
Renggli FJ, Meichtry A, Meier M, Adomeit P, Hess RG, Golz C.   +5 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

E-government and organisation development.

, 2004
This study presents an overview of the synergies between organisation change and ICT developments. It provides important insights into the way e-government is planned, implemented and evaluated at organisation level.
O'Donnell, Orla, O’Donnell, Orla, Boyle, Richard   +2 more
core  

Interorganisational Patient Safety Incident Reports: An Analytical Perspective. [PDF]

Scand J Caring Sci
Tuppurainen J, Turunen H, Haatainen K.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Bologna changes in MA degree programmes. Convergence of the public administration programmes in South-Eastern Europe

The provisions of Bologna Declaration are ongoing implemented in several South- Eastern European states, members or non members of the European Union. For most states, important restructuring processes for the legal framework and organisation system of ...
Matei, Lucica
core  

Scientists' Warning to Humanity: Unnecessary Bureaucracy Is a Global Impediment to Productivity, Advancement of Human and Planetary Wellbeing, Science and Sustainability. [PDF]

Microb Biotechnol
Timmis K, Karahan ZC, Byrne JA, Robinson JM, Bernal P, Rainey PB, López-García P, McGenity TJ, Chavarria M, Sato K, Verstraete W, Blank LM, Lal R, Colom MF, Ramos JL.   +14 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source