Results 171 to 180 of about 743,839 (316)

Identifying research priorities for post-collision care in the United Kingdom: protocol for a road injury priority setting partnership. [PDF]

Scand J Trauma Resusc Emerg Med
Nutbeam T, Leech C, E Baker C, Box E, R Rodgers L, Dungay K, Johnson L, Lee B, MacQueen M, Fenwick R, Marritt I, Dunbar I, Barnard EBG.   +12 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Assessing the assessment: a scoping review of the mode of patient-reported outcome assessment in solid cancer clinical trials. [PDF]

Qual Life Res
Hubel N, Krepper D, van der Weijst L, Machingura A, Seidl C, Vorbach SM, Veil M, Giesinger JM, Sztankay M, Kern S, Fitzsimmons D, Kuliś D, Pe M, Holzner B, Lehmann J, EORTC Quality of Life Group.   +15 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Trauma-informed care (TIC) in low- and middle-income countries: A scoping review of organisational implementation efforts. [PDF]

Glob Ment Health (Camb)
Maiorano N, Wagner Manslau M, Sheaf G, Ó Súird M, Nadeem Akhtar T, Collins R, Doyle C, Sherif Karam D, Steltzner C, Ryan M.   +9 more
europepmc   +1 more source

Organisation and administration

, 2018
openaire   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

A Social Return on Investment Evaluation of the Expansion of an Allied Health Student Training Programme in Rural Australia. [PDF]

Aust J Rural Health
French L, Lander C, Green E, Nott M, Anderson G, Brusco NK.   +5 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Making sense of activity-based workplaces: perspectives from staff in a municipal setting. [PDF]

Int J Qual Stud Health Well-being
Wall E, Löfstrand P, Vinberg S, Selander J.   +3 more
europepmc   +1 more source