Results 111 to 120 of about 519,146 (302)

How does organisational culture influence the process of implementing PBL?

Journal of Problem Based Learning in Higher Education, 2018
With the growing demand to use pedagogical approaches to foster 21st-century skills such as problem solving, creativity, critical thinking, collaborative learning and innovation, problem-based learning (PBL) has been the pedagogical approach chosen by ...
Heilyn Camacho, Mayela Coto, Kenneth Mølbjerg Jørgensen   +2 more
doaj   +2 more sources

Towards a further understanding of the relationship between job attitudes and employees’ responses:the case of Greek banks in recessionary times [PDF]

, 2018
The 2008 global financial crisis is described as the deepest the world has experienced since the stock market crash in 1930s. This has led to a liquidity shortfall and solvency problems for most banking systems across the globe (Otero-Iglesias 2015 ...
Aravopoulou, Eleni, Branine, Mohamed, Mitsakis, Fotis   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Change agent or neutral bystander? An exploration of how the coaching practices of internal coaches in Higher Education Institutions support organisational change

International Journal of Evidence Based Coaching and Mentoring
The study explores how internal coaches working in the HE sector manage the interplay of individual change and organisational change, and the implications for undertaking a change agency role during the coaching process.
Amanda Maclean
doaj   +1 more source

Social gatekeepers and racial equality strategies in social housing [PDF]

This thesis theorises processes of change through an examination of formal and informal race equality strategies within a housing association. The literature review evaluates paradigms which seek to explain the differential housing experiences of ...
Tomlins, Richard
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Designing temperature sensors for rocket engine: Organisational change through technological innovation in a french SME. [PDF]

organisational ...
Lusin Bagla-Gokalp
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Change readiness in Central Java Government: Effect of leadership, political skill and learning culture

SA Journal of Human Resource Management
Orientation: Organisational change readiness plays a crucial role in the current change process, especially among leaders in government bureaucracy.
Theresia D. Setyorini, Marina Sulastiana, Zainal Abidin, Hendriati Agustiani   +3 more
doaj   +1 more source