Results 51 to 60 of about 309,929 (284)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Organisational trust, commitment and turnover intention in employees of domestic and foreign banks in Ghana

Cogent Business & Management
The study examined the relationship between organisational trust, organisational commitment and turnover intention among employees of banks in Ghana. Participants were drawn from both domestic banks and foreign-owned banks.
Thomas Addae Nketsiah, Emmanuel Anokye Nkansah   +1 more
doaj   +1 more source

Headmaster’s Transformational Leadership and Teacher’s Organisational Commitment in Primary School [PDF]

, 2008
The study aimed to explore the level of headmaster’s transformational leadership/the level of teachers/organizational commitment and the relationship between headmaster’s leadership style and the organisational commitment of primary school teachers in ...
Abd Latif, Rozita, Nazarudin, Mohamad Nizam, Omar Fauzee, Mohd Sofian   +2 more
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

The relationship between organisational commitment, job satisfaction and employee retention of detectives in the SAPS in the City of Tshwane

SA Journal of Human Resource Management
Orientation: Findings on the relationship between organisational commitment, job satisfaction, and employee retention have been inconsistent. Research purpose: The purpose of this study was to determine the relationship between organisational commitment,
Chuene S. Moshabi, Cecile M. Schultz, Francisca du Plessis   +2 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Relationship between job stress and organisational commitment among public servants in Pontian, Johor [PDF]

, 2016
This study was conducted to determine the relationship between job stress and organisational commitment among public servant in Pontian, Johor. 262 public servants were chosen as respondents of this study through random sampling technique.
Ahmad, Sa'odah, Roslan, Nor Fameza
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Organisational culture and organisational commitment: the moderating effect of self-efficacy [PDF]

Journal of Humanities and Applied Social Sciences
Purpose – This study aims at establishing the moderating role of self-efficacy in the relationship between organisational culture (OC) and organisational commitment in the perspective of institutions of higher learning in a developing country.
Julius Samuel Opolot, Charles Lagat, Stanley Kipkwelon Kipsang, Yonah Katto Muganzi   +3 more
doaj   +1 more source