Results 61 to 70 of about 803,924 (317)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Ethical legal aspects in assisted reproductive technologies [PDF]
Vojnosanitetski Pregled, 2008 Dragojević Svetlana +5 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
THE CONSIDERATIONS RELATING TO THE EFFECTS OF TOXIC SUBSTANCES FROM THE ENVIRONMENT ON THE ORGANISM [PDF]
Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2019 This paper presents aspects regarding the toxic effects that certain substances such as polycyclic aromatic hydrocarbons, heavy metals and other carcinogens exert on the human body and how they influence the health of the population.
Daniela Cîrţînă +2 more
doaj
Linking Supply Chain Disruption Orientation to Supply Chain Resilience and Market Performance with the Stimulus–Organism–Response Model [PDF]
, 2022 Aaron Rae Stephens +2 more
openalex +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
AstérionStarting from the first occurrences in French of ‘esprit de corps’ (Saint-Simon, Voltaire), this article investigates this phrase’s philosophical and metaphorical presuppositions of eighteenth-century uses.
Matteo Marcheschi
doaj +1 more source
What's that thing called embodiment? [PDF]
Avant, 2015 Embodiment has become an important concept in many areas of cognitive science. There are, however, very different notions of exactly what embodiment is and what kind of body is required for what type of embodied cognition.
Tom Ziemke
doaj
Mode switching in organisms for solving explore-versus-exploit problems [PDF]
, 2023 Debojyoti Biswas +6 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source