Results 141 to 150 of about 10,160,940 (341)

BİREYSEL AYRILIKLAR ve TOPLUMSAL DEZAVANTAJLAR ÇERÇEVESİNDE İŞYERİNDE PSİKOLOJİK TACİZ: MOBBİNG

open access: yesMehmet Akif Ersoy Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi, 2015
Çalışma hayatı, kişinin rutin yaşamının bir parçası olmakla birlikte, özellikle Türkiye gibi toplumlarda büyük bir parçası olmaktan ötürü, bireyi geniş çaplı bir boyutta etkileyen ve belirleyen nitelikler göstermektedir.
Meriç Pehlivan
doaj  

Cloud Versus Void Chord Length Distributions (LvL) as a Measure for Cloud Field Organization

open access: yesGeophysical Research Letters
Cloud organization impacts the radiative effects and precipitation patterns of the cloud field. Deviating from randomness, clouds exhibit either clustering or a regular grid structure, characterized by the spacing between clouds and the cloud size ...
Ilan Koren   +3 more
doaj   +1 more source

Fall prevention for people with learning disabilities: key points and recommendations for practitioners and researchers [PDF]

open access: yes, 2018
National Institute for Health Care and Excellence (NICE)   +2 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Molecular Organization and Functional Analysis of a Novel Plasmid-Borne cps Gene Cluster from Lactiplantibacillus plantarum YC41

open access: gold, 2023
Jieran An   +12 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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