Results 141 to 150 of about 802,580 (259)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Tracking governance and administration expenditure under the System of Health Accounts 2011

vi, 26 p.This document analyses country practices for measuring expenditure on governance and health system and health financing administration under the System of Health Accounts (SHA) 2011 framework.
World Health Organization
core  

Science-policy translation for Lassa fever control in West Africa: a qualitative synthesis of regional evidence. [PDF]

Trans R Soc Trop Med Hyg
Lokossou VK, Usman AB, Sombie I, Omeje O, Umeokonkwo CD, Sogbossi L, Johson E, Adegbite BR, Tchamdja K, Mongbo Y, de Hardt-Kaffils H, Manigart O, Oyebanji O, Ramsauer K, Anueyiagu C, Ndir A, Kaduru C, Ezenyi I, Ilori E, Ihekweazu V, Anyakora C, Agaboye K, Ndem A, Boton L, Keita N, Cardoso P, Hounkpe N, Ale F, Batonon A, Boya L, Adohinzin C, Agbla F, Janneh H, Aïssi MA.   +33 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Regarding emergency medical services activation after epinephrine for anaphylaxis. [PDF]

World Allergy Organ J
Bahna SL.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Functional matrix engineering enables aggregate-state photophysics in tumor-responsive organic NIR-II phototheranostics. [PDF]

Mater Today Bio
An L, Ou C, An H, Sun H, Mou X, Dong X, Cai Y.   +6 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Nintedanib Treatment of Patients With Interstitial Lung Diseases: A Retrospective Study of Daily Clinical Practice. [PDF]

In Vivo
Miyazaki K, Sato S, Kodama T, Kawakami T, Yazaki K, Matsuyama M, Tamura T, Numata T, Hayashi S, Inui T, Maezawa Y, Satoh H, Shiozawa T, Kikuchi N, Hizawa N.   +14 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source