Results 81 to 90 of about 2,914,629 (340)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Redefining managerial effectiveness in a multilevel organization : a structurationist account [PDF]

open access: yes
Many organization theories consist of an interpretation frame and an idea about the ideal equilibrium state. This article explains how the equilibrium concept is used in four organization theories: the theories of Fayol, Mintzberg, Morgan, and Volberda ...
Offenbeek, M. van, Paul, L.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Knowledge and power necessary to reconstruct nursing after management changes at a teaching hospital Conocimientos y poderes necesarios para reconstruir la enfermería frente a los cambios administrativos en un hospital de enseñanza Saberes e poderes necessários à reconstrução da enfermagem frente a mudanças gerenciais num hospital de ensino

open access: yesRevista Latino-Americana de Enfermagem, 2008
This study was carried out at a teaching hospital in Southern Brazil, which adopted a management model that provoked the dismantling of the nursing service and the disbandment of nursing professionals.
Elizabeth Bernardino   +1 more
doaj   +1 more source

Traditional Athabascan Law Ways and Their Relationship to Contemporary Problems of "Bush Justice": Some Preliminary Observations on Structure and Function. [PDF]

open access: yes, 1972
This paper is directed toward helping achieve a better understanding of traditional law ways among Alaska's Athabascan Indians and of the present state of the administration of law in the "bush"-village Alaska.
Conn, Stephen, Hippler, Arthur E.
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Evaluation of Viewpoint of Executive Management Team of Hospitals of Qom Province in Terms of the Third Generation of Hospital Accreditation Standards, 2017, (Iran)

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2018
Background and Objectives: Hospital accreditation is used as a tool to improve the quality and safety of patients. The effectiveness of accreditation depends on the content of the standards.
Mohammad Ali Fotuhi   +4 more
doaj  

HOW TO INCREASE EMPLOYEE’S DISCIPLINARY IN FACULTY MEDICINE OF DIPONEGORO UNIVERSITY [PDF]

open access: yes, 2012
Human Capital plays an important role in organization. It is the heart of the organization strategy. Many factors embeded in it. Public Service employees as government human capital instead of the contract employees.
SETYOWATI, RETNO
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Portuguese intermunicipal organization - Basic principles [PDF]

open access: yes
Portuguese territorial organization has two levels of territorial decision support legitimated: central and local/municipal government (municipalities).
Rui Alves
core  

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