Results 161 to 170 of about 1,023,510 (318)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The Organizational Fitness Navigator: Creating and Measuring Organizational Fitness for Fast-Paced Transformation [PDF]

In the fast-changing environment of today dynamic capabilities to manage organizational transformation are regarded as crucial for business survival and improved performance.
Voelpel, Sven C., Leibold, Marius, Mahmoud, Khalid M.   +2 more
core  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Organizational factors and safety: The mediation effects of organizational processes

, 2010
The research of safety related organizational factors is hampered for two reasons: 1, accident retrospect analysis is always single-direction, it is hard to make conclusion what is the effect of some organizational factors even some accident ...
Wang EP(王二平), Shi W
core  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Toward a Deeper Understanding of Organizational Theory: An Organizational Performance Scale for Third-Sector Institutions in Latin America

Various corporate groups, such as third-sector institutions in Latin America, have shown increasing interest in evaluating organizational performance as a possible strategy for increasing their effectiveness and competitiveness.
Elizabeth Emperatriz García-Salirrosas, Ruth Alexandra Bejarano-Chalá, Miluska Villar-Guevara   +2 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Bridging intra-organizational borders – Middle managers’ interventions as a contribution to organizational learning

, 2011
The extent, to which middle managers mainly execute decisions made by higher-level managers in the authority hierarchy, or substantially take part in those decisions, varies with business habits and company cultures. Where middle managers do get involved
Wilhelmson, Lena,, Johansson, Peter,, Döös, Marianne,   +2 more
core  

The impact of value-based leadership on employee innovative behavior: the mediating role of organizational identification and moderating role of person-organization matching. [PDF]

Front Psychol
Liang R.
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source