Results 91 to 100 of about 77,933 (256)

Spatiotemporal dynamics of NF-κB/Dorsal inhibitor IκBα/Cactus in Drosophila blastoderm embryos

iScience
Summary: The NF-κB/IκBα pathway regulates key cellular processes, including development, immunity, and inflammation. In Drosophila, the homologous Dorsal/Cactus system patterns the dorsoventral axis of the blastoderm embryo.
Allison E. Schloop, Sharva Vijayakumar Hiremath, Razeen Shaikh, Sadia Siddika Dima, Leslie Lizardo, Amrit Bhakta, Cranos M. Williams, Gregory T. Reeves   +7 more
doaj   +1 more source

In Vivo F-Actin Filament Organization during Lymphocyte Transendothelial and Interstitial Migration Revealed by Intravital Microscopy

iScience, 2019
Summary: Actin is essential for many cellular processes including cell motility. Yet the organization of F-actin filaments during lymphocyte transendothelial migration (TEM) and interstitial migration have not been visualized.
Serena L.S. Yan, Il-Young Hwang, Olena Kamenyeva, John H. Kehrl   +3 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

The Concept of Mechanism in Biology [PDF]

, 2012
The concept of mechanism in biology has three distinct meanings. It may refer to a philosophical thesis about the nature of life and biology (‘mechanicism’), to the internal workings of a machine-like structure (‘machine mechanism’), or to the causal ...
Nicholson, Daniel J.
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The communication of meaning in social systems

, 2008
The sociological domain is different from the psychological one insofar as meaning can be communicated at the supra-individual level (Schutz, 1932; Luhmann, 1984). The computation of anticipatory systems enables us to distinguish between these domains in
Aoki, Collier, Dubois, Dubois, Dubois, Dubois, Giddens, Habermas, Habermas, Hesse, Husserl, Lakoff, Leydesdorff, Leydesdorff, Leydesdorff, Leydesdorff, Leydesdorff, Leydesdorff, Leydesdorff, Leydesdorff, Leydesdorff, Luhmann, Luhmann, Luhmann, Luhmann, Luhmann, Luhmann, Luhmann, Luhmann, Luhmann, Luhmann, Luhmann, Luhmann, Luhmann, Luhmann, Maasen, MacKay, Maturana, Maturana, May, May, Mead, Parsons, Rosen, Schutz, Schütz, Shannon, Spencer-Brown   +47 more
core   +2 more sources

Retractions in Rheumatology: Trends, Causes, and Implications for Research Integrity

Arthritis Care &Research, EarlyView.
Objective We aimed to describe the trends and main reasons for study retraction in rheumatology literature. Methods We reviewed the Retraction Watch database to identify retracted articles in rheumatology. We recorded the main study characteristics, authors’ countries, reasons for retraction, time from publication to retraction, and trends over time ...
Anna Maria Vettori, Michele Iudici
wiley   +1 more source

Cab45G trafficking through the insulin secretory pathway is altered in human type 2 diabetes

iScience
Summary: In type 2 diabetes (T2D), the rate of insulin secretory granule biogenesis can limit insulin secretion from pancreatic β-cells. Using rat insulinoma INS1 β-cells, we show that the soluble Ca2+-binding/trafficking protein, Cab45G, serves as a non-
Mark Germanos, Belinda Yau, Matthew Taper, Cara Yeoman, Amy Wilson, Yousun An, Jerome Cattin-Ortolá, Drew Masler, Jason Tong, Sheyda Naghiloo, Elise J Needham, A Gabrielle van der Kraan, Kitty Sun, Thomas Loudovaris, Alexis Diaz-Vegas, Mark Larance, Helen Thomas, Helen von Blume, Peter Thorn, Michael Ailion, Cedric Asensio, Melkam Alamerew Kebede   +21 more
doaj   +1 more source

Advancing Research on Biomaterials and Biological Materials with Scanning Electron Microscopy under Environmental and Low Vacuum Conditions

Advanced Engineering Materials, EarlyView.
Herein, environmental scanning electron microscopy (ESEM) is discussed as a powerful extension of conventional SEM for life sciences. By combining high‐resolution imaging with variable pressure and humidity, ESEM allows the analysis of untreated biological materials, supports in situ monitoring of hydration‐driven changes, and advances the functional ...
Jendrian Riedel, Lea Dierker, Antoine Eyram Kwame, Kim Nora Wagner, Jonas J. Unterholzner, Jan‐Henning Dirks, Dorothea Brüggemann   +6 more
wiley   +1 more source

Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip

iScience, 2019
Summary: We leveraged a human gut-on-a-chip (Gut Chip) microdevice that enables independent control of fluid flow and mechanical deformations to explore how physical cues and morphogen gradients influence intestinal morphogenesis.
Woojung Shin, Christopher D. Hinojosa, Donald E. Ingber, Hyun Jung Kim   +3 more
doaj   +1 more source

The Machine Conception of the Organism in Development and Evolution: A Critical Analysis [PDF]

, 2014
This article critically examines one of the most prevalent metaphors in modern biology, namely the machine conception of the organism (MCO). Although the fundamental differences between organisms and machines make the MCO an inadequate metaphor for ...
Nicholson, Daniel J.
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