Results 131 to 140 of about 6,765,960 (292)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Attitudes toward organizational change and their association with exhaustion in a sample of Italian police workers. [PDF]

Front Psychol, 2023
Colombo L, Acquadro Maran D, Grandi A.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The Link between HRM Practices and Performance in Healthcare: The Mediating Role of the Organizational Change Process. [PDF]

Healthcare (Basel), 2023
Rotea CC, Ploscaru AN, Bocean CG, Vărzaru AA, Mangra MG, Mangra GI.   +5 more
europepmc   +1 more source

Rethinking Organizational Change: The Role of Dialogue, Dialectic & Polyphony in the Organization

, 2016
This book applies Russian philosopher Mikhail Bakhtin's (1895-1975) anthropological concept of 'polyphony' to organizational change. Bakhtin's notion of 'utterances' and his distinction between 'monologue' and 'dialogue' help us to change the way that we
Jabri, Muayyad
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Organizational Change

Organisasi berubah dikarenakan adanya budaya, struktur, teknologi, pengaturan fisik, dan ...
  +4 more sources

Indigenous innovation and organizational change towards equitable higher education systems: the Canadian experience. [PDF]

AlterNative (Nga Pae Maramatanga (Organ)), 2023
Tamtik M.
europepmc   +1 more source

Organizational Innovation [PDF]

This paper examines the dynamic and multi-level relationship between organization and innovation from three different but interdependent perspectives: a) the relationship between organizational structural forms and innovativeness; b) innovation as a ...
Lam, Alice
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source