Results 81 to 90 of about 2,984,663 (345)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

JOB SATISFACTION MANAGEMENT AND ITS IMPACT ON BURNOUT AND TURNOVER AMONG AUDITORS

Agora International Journal of Economical Sciences
The paper examines managerial viewpoints related to job satisfaction, burnout, and turnover in auditing companies. Based on in-depth analysis using managerial viewpoints obtained through human resources managers’ or audit managers’ participation in face-
Revaz Lazariashvili, Natia Surmanidze
doaj   +1 more source

Conflict in Organizations [PDF]

, 2011
{Excerpt} Michael Cohen, James March, and Johan Olsen9 have developed an influential, agent-based representation of organizational decision-making processes.
Serrat, Olivier
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Organizational Aspects of Multicriteria Decision Making [PDF]

, 1980
Decision making processes include organizational or institutional aspects in which human judgement and reflection of the decision maker are formed. Thus, analysis of organizational behaviors in the decision making processes has been attracting increasing
Seo, F.
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

From Professional Business Partner to Strategic Talent Leader : What’s Next for Human Resource Management [PDF]

, 2002
The HR profession is at a critical inflection point. It can evolve into a true decision science of talent, and aspire to the level of influence of disciplines such as Finance and Marketing, or it can continue the traditional focus on support services and
Boudreau, John W., Ramstad, Peter M.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Emotional intelligence, support, and organizational culture’s impact on decision-making: mediation and moderation analysis in academia

Discover Education
Academic decision-making is composite, involving a number of players with various points of view and frequently conflicting interests. This study explored the relationship between emotional intelligence competence, organizational support, complexity of ...
Saqib Munir, Muhammad Khalid Anser, Syed Tahir Hussain Shah, Talat Islam, Khalid Zaman   +4 more
doaj   +1 more source

The Impact of Organizational Citizenship Behavior, Employee Engagement, and Managerial Decision-Making on the Microfinance Institutions Performance

Media Ekonomi dan Manajemen
This study examines the impact of employee organizational citizenship behavior (OCB) and engagement on the performance of microfinance institutions, with a focus on the moderating role of managerial decision-making.
Donni Junipriansa, Ganjar Mohamad Disastra   +1 more
doaj   +1 more source