Results 51 to 60 of about 193,824 (315)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

A Bibliometric Analysis of Organizational Innovation, Organizational Sustainability, Organizational Performance, and Management Models [PDF]

open access: yesRevista de Management Comparat International
This paper presents an assessment of the themes organizational innovation, organizational sustainability, organizational performance, and management models for the period 2019-2024.
Adela MUSTATEA
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Modeling Organizational Architectural Styles in UML [PDF]

open access: yes, 2003
Today's information systems operate within a dynamic, organizational context and consequently require flexible architectures to ensure that they remain operational and useful. The Tropos software development methodology is founded on the premise that social and intentional concepts (such as those of actor and goal) can be used throughout the ...
J. Castro, C. Silva, Mylopoulos, Ioannis
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Middle managers’ role in organizational commitment and organizational citizenship behaviours [PDF]

open access: yes, 2015
“Any motivated behavior, either preparatory or consummatory, must be understood to be a channel through which many basic needs may be simultaneously expressed or satisfied.
Landa, Clive H.
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

The Impact of Applying Excellence Models on Enhancing Organizational Performance, An empirical study on the Information and Decision Support Center (IDSC) of the Egyptian Cabinet [PDF]

open access: yesالمجلة العلمية للدراسات والبحوث المالية والتجارية
This study aimed to investigate the impact of applying excellence models on enhancing organizational performance through the empirical study on the Information and Decision Support Center (IDSC) of the Egyptian Cabinet.
Mohamed Abd El-Kader Shehab El-Din   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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