Results 61 to 70 of about 1,154,495 (307)

Modeling Organizational Project Management [PDF]

Project Management Journal, 2019
The contemporary discourse on organizational project management (OPM) complements project, program, and portfolio management with emerging elements, such as governance, projectification, the project management office (PMO), and organizational design. This creates the need for an integrated model that defines the content and roles in OPM.
Müller, Ralf Josef, Drouin, Nathalie, Sankaran, Shankar   +2 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A comparison of social media marketing between B2B, B2C and mixed business models [PDF]

, 2018
This paper explores the implicit assumption in the growing body of literature that social media usage is fundamentally different in business-to-business (B2B) companies than in the extant business-to-consumer (B2C) literature.
Archer-Brown, Chris, Davies, Iain, Iankova, Severina, Marder, Ben, Yau, Amy   +4 more
core   +6 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Impact of the Organization on the Autonomy of Agents

Information
In multi-agent systems (MAS), autonomy is a fundamental characteristic that enables agents to operate independently and adaptively within complex environments. However, such characteristics may cause the system to fall into undesirable situations. On the
Zouheyr Tamrabet, Djamel Nessah, Toufik Marir, Varun Gupta, Farid Mokhati   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The Emergence of Non-Traditional Cooperative Structures: Public and Private Policy Issues [PDF]

This paper examines new agricultural cooperative organizational models from an ownership rights perspective. We argue that new cooperative organizational models differ in the way ownership rights are assigned to the economic agents tied contractually to ...
Chaddad, Fabio Ribas, Cook, Michael L.
core   +1 more source

A framework for the definition of metrics for actor-dependency models [PDF]

, 2004
Actor-dependency models are a formalism aimed at providing intentional descriptions of processes as a network of dependency relationships among actors. This kind of models is currently widely used in the early phase of requirements engineering as well
Franch Gutiérrez, Javier, Grau Colom, Gemma, Quer, Carme   +2 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source