Results 111 to 120 of about 879,653 (285)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Decreasing the Resistance of the Human Resources to Organizational Changes [PDF]
One of the most difficult problems faced by the management of all organizations within innovation and change processes is the resistance to change. This study, dealing with this issue, has the following main objectives: to identify the main sources of ...
Ciprian NICOLESCU, Ovidiu NICOLESCU
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Human Resouces Professional Formation and Development Policy [PDF]
Professional formation in organizations is a planned process that aims to change the three psychological attitudes, knowledge, abilities / skills / capabilities - with the clear purpose of achieving high performance in an activity or a range of ...
Aurel NEAGU, Cezar BRAICU, Cibela NEAGU
core
Adverse events in veterans affairs inpatient psychiatric units: Staff perspectives on contributing and protective factors. [PDF]
, 2017 OBJECTIVES: This study sought to identify risk factors and protective factors in hospital-based mental health settings in the Veterans Health Administration (VHA), with the goal of informing interventions to improve care of persons with serious mental ...
Cullen, Sara W. +4 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Agile methodologies for the digital transformation of a Colombian telecommunications company
TESEA, Transactions on Energy Systems and Engineering ApplicationsContemporary business dynamics drive the adoption of agile methodologies as an effective response to rapid market evolution and the need for organizational adaptability.
Juan Sebastián Sánchez Gómez +2 more
doaj +1 more source
Strategy and Structure: Explaning the Diversification Discount [PDF]
In this paper we provide an explanation based on the conflict of interes between top management, middle management and shareholders of why firms adopt different diversification strategies and how they structure themselves to manage those diversification ...
Felipe Balmaceda
core
Aligning Employees Through \u3ci\u3eLine of Sight\u3c/i\u3e [PDF]
, 2006 Aligning employees with the firm’s larger strategic goals is critical if organizations hope to manage their human capital effectively and ultimately attain strategic success.
Bingham, John B +2 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source