Results 101 to 110 of about 879,653 (285)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Cadernos de Saúde PúblicaO autor, inicialmente, apresenta algumas considerações encontradas no campo da Teoria Geral da Administração, sobre o papel da definição de "objetivos organizacionais" em um processo de mudança das organizações em geral.
Luiz Carlos de Oliveira Cecilio
doaj
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Journal of Management Small and Medium Enterprises (SME's)The research objectives are to examine the influence of self-efficacy and organizational culture on organizational citizenship behavior (OCB) with organizational commitment as an intervening variable.
Tini Kartini +2 more
doaj +1 more source
Corporate Governance as an instrument of change state owned Corporate Governance as an instrument of change state owned companies: The case of the Hellenic Telecommunications Organization [PDF]
This paper analyses the evolution of Corporate Governance (CG) mechanisms and organizational changes of the Hellenic Telecommunication Organization (HTO) and has two objectives: to enrich the debate and to contribute to the increasing body of literature ...
Demetrios Papoulias, Loukas Spanos
core
Enterprise Risk Management: Review, Critique, and Research Directions [PDF]
, 2015 © 2014 Elsevier Ltd. Many regulators, rating agencies, executives and academics have advocated a new approach to risk management: Enterprise Risk Management (ERM).
Bromiley, P +3 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Can we evaluate network brokerage initiatives using data that are byproducts of the network broking process? [PDF]
Increasingly, development projects list social capital development and network brokerage among their objectives. How do we quantitatively evaluate such initiatives? Best practice, diff-in-diff methods may be impossible or too costly.
Abigail Barr +3 more
core
A Theoretical Exploration of the Adoption and Design of Flexible Benefit Plans: A Case of Human Resource Innovation [PDF]
, 1997 This article explores theoretical explanations of managers\u27 decisions about flexible benefit plans. We (1) examine the adoption and design of flexible benefit plans through four theoretic lenses: institutional, resource dependence, agency, and ...
Barringer, Melissa W. +1 more
core +1 more source