Results 101 to 110 of about 1,480,841 (308)

Impact of Strategic Planning on Organizational Performance and Survival [PDF]

, 2010
The study examined the impact of strategic planning on organizational performance and survival. The effectiveness of strategic planning can be measured in terms of the extent to which it influences organizational performance, which affects its survival ...
Akinyele, S.T., Fasogbon, O.I.
core  

Organizational Mortality of Small Firms: The Effects of Entrepreneurial Age and Human Capital [PDF]

, 1990
This paper addresses the issue of internal determination of organizational outcomes. It is argued that in small and simply structured organizations a considerable proportion of the variance in organizational activities and outcomes is associated with ...
Aldrich, Howard, Becker, Gary S., Birch, David L., Blossfeld. Hans-Peter., Bogenhold, Dieter, Clemens, Reinhard, Cochran, A.B., Diekmann, Andreas, Fichman, Mark, Hannan, Michael T., Kalbfleisch, John D., Kanter, Rosabeth M., Klandt. Heinz, Mincer, Jacob, Mintzberg, Henry, Mintzberg, Henry, Peter Preisendörfer, Schußler, Rudolf, Schüßler, Rudolf, Szyperski, Norbert, Szyperski, Norbert., Thomas Voss, Tuma, Nancy B., Tuma, Nancy B., Weitzel. Günter, Williamson, Oliver E.   +25 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

PERAN BUDAYA ORGANISASI DALAM MEMEDIASI PENGARUH GAYAKEPEMIMPINAN DAN ETIKA TERHADAP KINERJA PERUSAHAN

MIX: Jurnal Ilmiah Manajemen, 2018
: The purpose of this study was to tested and explained empirically about (1) the effect of leadership style on the organizational performance, (2) the effect of ethic on the organizational performance, (3) the effect of leadership style on the ...
Deni Risianto, Dodi W. Irawanto, Mugiono Mugiono   +2 more
doaj   +1 more source

Measuring Organizational Performance in Strategic Human Resource Management: Looking Beyond the Lamppost [PDF]

, 1998
A major challenge for Strategic Human Resource Management research in the next decade will be to establish a clear, coherent and consistent construct for organizational performance.
Rogers, Edward W., Wright, Patrick M.
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Green human capital and organizational performance: The role of employee environmental awareness and sustainable innovation in achieving organizational sustainability

Innovation and Green Development
This research investigates the intricate relationships among Green Human Capital (GHC), Employee Environmental Awareness (EEA), sustainable innovation, organizational performance, and organizational sustainability within the unique context of Indonesian ...
Ika Pratiwi, Asep Saefudin, Gema Ika Sari, Budi Ilham Maliki, Fauzi, Soenyono, Basrowi, Uli Wildan Nuryano   +7 more
doaj   +1 more source