Results 121 to 130 of about 9,349,190 (294)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Organizational factors associated with supply chain management performance

, 2018
The concept of supply chain management (SCM) is receiving greater attention among academics and organizations and is viewed as a potential source of bottom and top-line growth. Despite the potential for improving organizational performance through supply
Bell, Gregory A.
core  

Enhancing Performance: The Role of Organizational Culture, Commitment, and Support in Indonesian Paper Industry

Jurnal Psikologi
Human resources play an important role in the successful achievement of performance. Employee performance is the result of the work achieved by employees in a company.
Nidya Dudija, Sartika Naibaho, Satrio Budi Wibowo   +2 more
doaj   +1 more source

The Relationship Between Employee Satisfaction and Perceived Organizational Performance

Employee satisfaction remains a central theme in management, with substantial evidence linking it to organizational performance. This study examines the nature and strength of that relationship and investigates whether its magnitude varies across ...
Gylfi Dalmann Adalsteinsson, Magnus Haukur Asgeirsson, Thorhallur Gudlaugsson   +2 more
core   +1 more source

THE USEFULNESS OF MANAGEMENT ACCOUNTING SYSTEMS, FUNCTIONAL DIFFERENTIATION AND MANAGERIAL EFFECTIVENESS [PDF]

, 1994
~tis study examines the role of broad scope information, made available by management accouming system* (MAS), in enchanging mamgerial performance.
CHENHALL, ROBERT H., Mia, Lokman
core  

Reviewing Performance or Changing Routines? An Analysis of the Experience of Participants in Performance Management Review Meetings [PDF]

, 2010
The problem examined in this thesis falls under the broad question of the nature of effect of performance measurement and management (PMM) on organizational performance.
Pavlov, Andrey
core   +1 more source

Organizational Performance

, 2016
  +6 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source