Results 101 to 110 of about 1,051,672 (307)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Succession planning for organizational stability
Nursing Management, 2021 Christina M, Martin, Kristen, O'Shea
openaire +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Assessment of Professional Competences. Constructive Dimension of Human Resources Management [PDF]
The present article proposes a model of how to develop a plan for evaluate professional skills, applicable to people who want to certify skills acquired in non-formal ways and also in human resource departments, that want to evaluate professional skills ...
Ph.D. Antonio SANDU, Simona PONEA
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Manajemen Sumber Daya Manusia (MSDM) Pada Lembaga Pendidikan
An Nuha: Jurnal Kajian Islam, Pendidikan, Budaya & Sosial, 2018 Conceptually human resource management in Indonesia is focused on understanding plan, implementing plan, and greater attention to managerial aspects and better utilization of people as organizational resources. In other words, human resource management
Khoirunnisaa' Khoirunnisaa'
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Strategic Plan of Iranian Medical Sciences Universities: From Theory to Practice
مدیریت اطلاعات سلامت, 2016 Introduction: A strategic plan provides the context for improving organizational performance by accurate, extensive, and in-depth identification and analysis of interior and exterior environments.
Seiyed Davood Nasrollapour-Shirvani +3 more
doaj
Sosyal Ekonomik Araştırmalar Dergisi, 2009 Büro çalışma alanlarının geliştirilmesi önerildiğinde çok sık olarak akla gelen; “verimlilik üzerinde ne gibi etkiler bekleyebiliriz?” sorusudur. Yöneticiler ya da işverenler, büro tasarımı için yapılan yatırımların, kurumsal verimlilik ile ilgili ...
Mehmet Altınöz, Ramazan Göral
doaj +4 more sources