ORGANIZATIONAL IMPROVEMENT PLAN [PDF]
, 2018 Within the constraints of competing ideologies; Indigenous vs Western knowledge, health service leaders committing to embedding cultural safety and humility into health care services for Indigenous peoples, and the broader change of direction laid out by the Truth and Reconciliation Commission of Canada (2015), is the overall need to improve health ...
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
آفاق جدیدة للعلوم الاجتماعیة بجمهوریة مصر العربیة لتطویر اداء المنظمات باستخدام نظم المعلومات التخطیطیة " دراسة مقارنة " New Horizons for Social Sciences in The Arab Republic of Egypt to Develop The Performance of Organizations Using Planning Information Systems "Comparative Study" [PDF]
, 2021 مصطفى على احمد عبد المولى
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Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Succession planning for organizational stability
Nursing Management, 2021 Christina M, Martin, Kristen, O'Shea
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The World Hypertension League Challenges Hypertension and Cardiovascular Organizations to Develop Strategic Plans for the Prevention and Control of Hypertension [PDF]
, 2015 Norm R.C. Campbell +6 more
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Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source