Results 111 to 120 of about 13,539,650 (335)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Hermeneutic Lens

Estudios Sociales Contemporáneos
Discourse Analysis became mainstream in Organizational Studies. While some easily recognize discourse as one of the most expressive contemporary organizational phenomena, others consider its onto-epistemological and theoretical-methodological aspects to
Paulo Marcelo Ferrarese Pegino
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Shocking the System: The Athletic, a Journalistic Merger and the (Preventable) Ensuing Fallout

International Journal of Communication
This case study applies systems theory to examine the merger between The Athletic and The New York Times from the perspective of Athletic journalists. As media mergers increase, research on their successes and failures can illuminate the tensions at the
Patrick Ferrucci, Gregory P. Perreault
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Consciência política e participação no Orçamento Participativo em Cachoeiro de Itapemirim (ES, 2009-2012)

Ciências Sociais Unisinos, 2015
The objective of this article is to understand the dynamics of political consciousness and citizen participation in Participatory Budgeting (PB) in Cachoeiro de Itapemirim (Espírito Santo State, Brazil) during 2009-2012.
Leandro Vianna Silva Souza, Marcia Prezotti Palassi, Alfredo Rodrigues Leite da Silva   +2 more
doaj  

A influência de Maurício Tragtenberg na obra da primeira geração de pesquisadores nos Estudos Organizacionais críticos brasileiros

Cadernos EBAPE.BR
Resumo: Influenciar um campo acadêmico não é um papel desempenhado por muitos pesquisadores. No caso dos Estudos Organizacionais brasileiros, esse papel foi desempenhado por poucos.
André Luis Marra do Amorim, Camila Brüning   +1 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Perspective (Institute for Christian Studies)

, 1998
Strategic Directions. An important decision: an exciting future [non affiliation decision with The King’s University College], Strategic Directions: The road not taken [background to non affiliation decision with The King’s University College], Strategic
Meiboom, John, Fernhout, Harry, Cook, Hugh, Institute for Christian Studies, Sweetman, Robert, O’Brien, Kevin, Den Haan, Ed, VanderVennen, Robert E.   +7 more
core   +1 more source