Results 61 to 70 of about 206,186 (246)

Empirical study on organizational performance: the moderating effect of organizational culture

Pressacademia, 2020
Purpose- This study is based on IHPS BPK RI 2017 in the second semester. There are problems in terms of the performance of local governments in Lampung Province. The purpose of this study is to analyze the effect of 4 successful factors of AIS consisting: service quality, information quality, data quality, and system quality on organizational ...
HAFİZH, Muhammad Heno Rifdas, ASWAR, Khoirul   +1 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

An Ecological Model of Inter-institutional Sustainability of an After-school Program: The La Red Mágica Community-University Partnership in Delaware

Outlines, 2011
The purpose of the paper is to introduce a recursive model of ecological discursive sustainability, as it applies to and emerges from the history of an after-school program partnership between the School of Education at the University of Delaware, USA ...
Eugene Matusov, Mark Philip Smith
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

CRIMES CORPORATIVOS E ESTUDOS ORGANIZACIONAIS: UMA APROXIMAÇÃO POSSÍVEL E NECESSÁRIA [PDF]

RAE: Revista de Administração de Empresas, 2015
Corporate scandals have been common in contemporary society. In this context, the crimes committed in and by corporations also take form, and often we get to know a type of corporate crime, a topic not explored in organizational studies.
Cintia Rodrigues de Oliveira Medeiros
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

O Sujeito na Epistemologia Lacaniana e sua Implicação para os Estudos Organizacionais

Cadernos EBAPE.BR
Resumo: Este artigo discute a problemática do sujeito no âmbito do movimento pós-estruturalista, sobretudo na epistemologia lacaniana, e seu rompimento com a visão tradicional do sujeito na modernidade, refletindo sobre sua influência nas teorias ...
Ketlle Duarte Paes, Eloise Helena Livramento Dellagnelo   +1 more
doaj   +1 more source