Results 81 to 90 of about 217,468 (218)

Shocking the System: The Athletic, a Journalistic Merger and the (Preventable) Ensuing Fallout

International Journal of Communication
This case study applies systems theory to examine the merger between The Athletic and The New York Times from the perspective of Athletic journalists. As media mergers increase, research on their successes and failures can illuminate the tensions at the
Patrick Ferrucci, Gregory P. Perreault
doaj  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

O objeto objeto na análise organizacional: a teoria ator-rede como método de análise da participação dos não-humanos no processo organizativo

Cadernos EBAPE.BR
O objetivo deste artigo é analisar os objetos e elementos não-humanos como agentes constituintes do processo organizativo, por meio de uma abordagem pós-humanista: a teoria ator-rede.
César Tureta, Rafael Alcadipani
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Consciência política e participação no Orçamento Participativo em Cachoeiro de Itapemirim (ES, 2009-2012)

Ciências Sociais Unisinos, 2015
The objective of this article is to understand the dynamics of political consciousness and citizen participation in Participatory Budgeting (PB) in Cachoeiro de Itapemirim (Espírito Santo State, Brazil) during 2009-2012.
Leandro Vianna Silva Souza, Marcia Prezotti Palassi, Alfredo Rodrigues Leite da Silva   +2 more
doaj  

The development of institutional theory in the field of organization studies in Brazil

Cadernos EBAPE.BR
This article is based on the assumption that the construction of scientific knowledge is a social process characterized by the recursive dynamic between the social and intellectual dimensions.
Edson Ronaldo Guarido Filho, Clóvis L. Machado-da-Silva   +1 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Appropriation and rationality in hip hop groups organization practices in Porto Alegre: an analysis on the perspective of Guerreiro Ramos

Cadernos EBAPE.BR
This paper discusses the organizational practices of hip hop groups from Porto Alegre, southern Brazil, as they appropriate foreign experience and rationally guide their social action.
Guilherme Dornelas Camara, Sueli Goulart, Rafaela Mendes Reinher   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source