Results 91 to 100 of about 4,744,796 (313)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Entrepreneurial bricolage: A systematic literature network analysis and TCCM approach
Scientific AfricanIn recent years, bricolage, often considered an alternative approach to traditional methods of entrepreneurial action, has attracted increasing interest from researchers. This article aims to provide an in-depth overview of the current state of bricolage
Brahim Aaouid +3 more
doaj +1 more source
Resource Directory for Nonprofit Capacity Building in California's Central Valley [PDF]
, 2006 Provides an overview of recent studies of Central Valley's nonprofit sector, and a list of consultants, foundations, community organizations, and other institutions that provide capacity building services and resources to nonprofit ...
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Non-homothetic preferences, optimal public finance policy, and structural transformation
Cogent Economics & FinanceThis study uses a comparative perspective to investigate how fiscal policies and budgetary mechanisms influence structural economic changes. By constructing a theoretical model rooted in the government’s non-homothetic preferences, we analyze how fiscal ...
Yao Kouwonou, Koffi Sodokin
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Formale Methoden der Netzwerkanalyse in den Geschichtswissenschaften: Warum und Wie?
Österreichische Zeitschrift für Geschichtswissenschaften, 2012 The article presents a critical overview of past and present research in the domain of networks in history, based both on methodological and theoretical perspectives.
Claire Lemercier
doaj +1 more source
Introduction to the Demography Volume [PDF]
, 1992 [Excerpt] This volume represents another effort by Research in the Sociology of Organizations to focus on a crucial issue in organizational sociology. In some of the previous volumes, we concentrated on organizations and professions (Volume 8, 1991), the
Bacharach, Samuel B, Tolbert, Pamela S
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Evaluation Practice of Regional Operational Programmes in Poland
Management and Business Administration. Central Europe, 2014 Purpose: The study concentrated on the process of evaluation of public programs currently implemented with the support of European Union funds in Poland.
Tomasz Kupiec
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