Results 101 to 110 of about 5,556,537 (365)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A novel homozygous splice-site variant in the FOCAD gene causing infantile liver cirrhosis and neutropenia: expanding disease phenotype and successful surgical treatment

Frontiers in Medicine
BackgroundProgressive liver cirrhosis in pediatric patients characterized by clinical and genetic variability. Infantile cirrhosis caused by biallelic variants in the FOCAD gene is an extremely rare multi-system disorder leading to the progressive liver ...
Ekaterina Nuzhnaya, Elena Zaklyazminskaya, Viktoriia Zabnenkova, Darya Akimova, Evgeny Tatarsky, Lana Dzik, Andrey Surkov, Andrey Surkov, Natalia Zhurkova, Andrey Filin, Aleksej Metelin, Anna Arakelyan, Viktoriya Savina, Arshak Babayan, Mikhail Skoblov, Natalia Semenova   +15 more
doaj   +1 more source

Rising to the Challenge: The Strategies of Social Service Intermediaries [PDF]

, 2012
During the past decade, "intermediary organizations" have proliferated across the nonprofit sector. These organizations are typically positioned between funding entities (e.g., government agencies, foundations and corporations) and direct service ...
Child Trends, Karen E. Walker, Lori Delale-O'Connor   +2 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Entrepreneurial bricolage: A systematic literature network analysis and TCCM approach

Scientific African
In recent years, bricolage, often considered an alternative approach to traditional methods of entrepreneurial action, has attracted increasing interest from researchers. This article aims to provide an in-depth overview of the current state of bricolage
Brahim Aaouid, Abdellah Elboussadi, Omar Boubker, Zakaria Nejjari   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Non-homothetic preferences, optimal public finance policy, and structural transformation

Cogent Economics & Finance
This study uses a comparative perspective to investigate how fiscal policies and budgetary mechanisms influence structural economic changes. By constructing a theoretical model rooted in the government’s non-homothetic preferences, we analyze how fiscal ...
Yao Kouwonou, Koffi Sodokin
doaj   +1 more source

Organizations [PDF]

, 2020

openalex   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Evaluation Practice of Regional Operational Programmes in Poland

Management and Business Administration. Central Europe, 2014
Purpose: The study concentrated on the process of evaluation of public programs currently implemented with the support of European Union funds in Poland.
Tomasz Kupiec
doaj