Results 81 to 90 of about 5,556,537 (365)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Analyzing the impact of competition policy on economic prosperity in the MENA region (2013–2023)

Social Sciences and Humanities Open
In the MENA region, where economic disparities and developmental challenges are prevalent, understanding the impact of competition policy is imperative. As these countries undergo significant economic reforms and strive for sustainable development, this ...
Mohammed EL-Khodary, Amine EL Kadri, Soukaina Alami Harrak   +2 more
doaj   +1 more source

Designing Administrative Organizations for Health Reform [PDF]

, 2008
Describes proposals to create new entities to research comparative effectiveness, make coverage decisions, manage health insurance markets, or offer a public health insurance plan.
Paul N. Van de Water
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Accountability, Strategy, and International Non-Governmental Organizations [PDF]

, 2001
Increased prominence and greater influence expose international non-governmental development and environmental organizations (INGOs) to increased demands for accountability from a wide variety of stakeholdersdonors, beneficiaries, staffs, and partners ...
A C Vakil, A Florini, A Gray, A Najam, A Pettifor, D A Johnson, D Korten, E C Fama, J Boli, J Clark, J Cutt, J Fisher, J Fox, L Jordan, L. David David Brown, M Edwards, M Edwards, M Edwards, M H Moore, M H Moore, M H Moore, M Keck, M Keck, M Leach, M Lindenberg, Mark H. Moore, P Uvin, R Offenheiser, R Zeckhauser, S Goose, S Khagram, S Paul   +31 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Religious Organizations [PDF]

We propose a model of religious organizations which relies on the ability of such organi-zations and personal utility shocks. We show how religious organizations arise endogenously and characterize their features.
Gilat Levy, Ronny Razin
core  

UA12/2/34 Student Handbook [PDF]

, 1963
1963-64 student handbook created for WKU students which gives a history of WKU, academic information regarding enrollment, services and facilities available to students, campus map and ...
WKU Student Activities, Organizations & Leadership
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Technology Acceptance Under Conditions of Digital Transformation: A TAM-Based Study in the Tourism Sector

Tourism and Hospitality
The acceptance and effective use of digital technologies constitute a critical prerequisite for the adaptability and sustainability of organizations in tourism and hospitality, particularly in environments characterized by technological acceleration and ...
Ioannis Mihos, Georgios Kokkinis
doaj   +1 more source