Results 71 to 80 of about 5,450,086 (313)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Analyzing the impact of competition policy on economic prosperity in the MENA region (2013–2023)

Social Sciences and Humanities Open
In the MENA region, where economic disparities and developmental challenges are prevalent, understanding the impact of competition policy is imperative. As these countries undergo significant economic reforms and strive for sustainable development, this ...
Mohammed EL-Khodary, Amine EL Kadri, Soukaina Alami Harrak   +2 more
doaj   +1 more source

Goals, organizational change, advocacy, diversity literacy, and sustainability: A checklist for diversity in cardiothoracic surgery training programs [PDF]

, 2020
Katherine A. Ortmeyer, Vignesh Raman, Chidinma Tiko-Okoye, Jairo Espinosa, David T. Cooke, Sandra L. Starnes, Cherie P. Erkmen   +6 more
openalex   +1 more source

Buffalo Arts and Culture Organizations [PDF]

, 2016
Open Buffalo and Partnership for the Public Good collaboratively compiled a directory of organizations that promote social justice through locally based arts and cultural programmatic efforts.
Open Buffalo
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

A novel homozygous splice-site variant in the FOCAD gene causing infantile liver cirrhosis and neutropenia: expanding disease phenotype and successful surgical treatment

Frontiers in Medicine
BackgroundProgressive liver cirrhosis in pediatric patients characterized by clinical and genetic variability. Infantile cirrhosis caused by biallelic variants in the FOCAD gene is an extremely rare multi-system disorder leading to the progressive liver ...
Ekaterina Nuzhnaya, Elena Zaklyazminskaya, Viktoriia Zabnenkova, Darya Akimova, Evgeny Tatarsky, Lana Dzik, Andrey Surkov, Andrey Surkov, Natalia Zhurkova, Andrey Filin, Aleksej Metelin, Anna Arakelyan, Viktoriya Savina, Arshak Babayan, Mikhail Skoblov, Natalia Semenova   +15 more
doaj   +1 more source

Entrepreneurial Community Development - Exploring Earned Income Activities and Strategic Alliances for Community Development Nonprofits [PDF]

, 2001
This paper examines social entrepreneurship from a community-development perspective. The target audience is community-development nonprofit organizations.
Ellen Stiefvater
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Network Organizations [PDF]

It is common to define a network organization as one that is fast and flexible in adapting to changes in the underlying environment. But besides the short-run advantages of adaptability, fast changes in the structure of the organization can also be ...
Fernando Vega-Redondo
core