Results 21 to 30 of about 887 (144)

Stereoselectively fluorinated N-heterocycles: a brief survey

Beilstein Journal of Organic Chemistry, 2013
The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules’ physical and chemical properties.
Xiang-Guo Hu, Luke Hunter
doaj   +1 more source

Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system

Beilstein Journal of Organic Chemistry, 2013
Regioselective conjugate 1,4-trifluoromethylation of α,β-unsaturated ketones by the use of shelf-stable electrophilic trifluoromethylating reagents, S-(trifluoromethyl)diphenylsulfonium salts and copper under mild conditions is described. A wide range of
Satoshi Okusu, Yutaka Sugita, Etsuko Tokunaga, Norio Shibata   +3 more
doaj   +1 more source

Enantioselective Benzylation and Allylation of α-Trifluoromethoxy Indanones under Phase-Transfer Catalysis

Molecules, 2019
The organo-catalyzed enantioselective benzylation reaction of α-trifluoromethoxy indanones afforded α-benzyl-α-trifluoromethoxy indanones with a tetrasubstituted stereogenic carbon center in excellent yield with moderate enantioselectivity
Yumeng Liang, Mayaka Maeno, Zhengyu Zhao, Norio Shibata   +3 more
doaj   +1 more source

Synthesis of enantiomerically pure (2S,3S)-5,5,5-trifluoroisoleucine and (2R,3S)-5,5,5-trifluoro-allo-isoleucine

Beilstein Journal of Organic Chemistry, 2013
A practical route for the stereoselective synthesis of (2S,3S)-5,5,5-trifluoroisoleucine (L-5-F3Ile) and (2R,3S)-5,5,5-trifluoro-allo-isoleucine (D-5-F3-allo-Ile) was developed.
Holger Erdbrink, Elisabeth K. Nyakatura, Susanne Huhmann, Ulla I. M. Gerling, Dieter Lentz, Beate Koksch, Constantin Czekelius   +6 more
doaj   +1 more source

Joy and Flustration with Organofluorine Compounds – A Fluorous Autobiography

CHIMIA, 2014
An overview is given about our work on fluoro-organic compounds, published or described in PhD theses between 1977 and 2013. After a discussion of structural F-effects and F-tagging applications the material is ordered by the various areas of ...
Dieter Seebach
doaj   +1 more source

The difluoromethylene (CF2) group in aliphatic chains: Synthesis and conformational preference of palmitic acids and nonadecane containing CF2 groups

Beilstein Journal of Organic Chemistry, 2014
The syntheses of palmitic acids and a nonadecane are reported with CF2 groups located 1,3 or 1,4 to each other along the aliphatic chain. Specifically 8,8,10,10- and 8,8,11,11-tetrafluorohexadecanoic acids (6b and 6c) are prepared as well as the singly ...
Yi Wang, Ricardo Callejo, Alexandra M. Z. Slawin, David O’Hagan   +3 more
doaj   +1 more source

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

Beilstein Journal of Organic Chemistry, 2013
In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research.
Grégory Landelle, Armen Panossian, Sergiy Pazenok, Jean-Pierre Vors, Frédéric R. Leroux   +4 more
doaj   +1 more source

Crystal structure landscape of conformationally flexible organo-fluorine compounds

CrystEngComm, 2016
The crystal structure landscape of an unsubstituted benzanilide was generated and a number of hypothetical structures were accessed with experimentally obtained crystal structures of mono-, di-, tetra- and penta-fluorobenzanilides.
Pradip Kumar Mondal, Deepak Chopra
openaire   +2 more sources

Direct Regioselective para‐Fluorination via I(I)/I(III) Catalysis

Angewandte Chemie International Edition, EarlyView.
A direct, para‐selective fluorination by I(I)/I(III) catalysis is disclosed that does not require substrate pre‐functionalization. This strategy leverages the Leonard link inherent to phenylpropanoate and phenylpropanamides to promote a spirocyclization/para‐selective sequence. The C3‐side chain maps onto a range of common drug scaffolds and allows the
Christoph Roblick, Julian D. Bendix, Timothy A. Hilton, Kathrin Bussmann, Constantin G. Daniliuc, Ryan Gilmour   +5 more
wiley   +1 more source