Results 1 to 10 of about 1,290 (130)

Dual-role iron species in photoelectrocatalytic radical trifluoromethylation with trifluoroacetates [PDF]

Nature Communications
Trifluoromethylation remains a fundamental transformation in drug discovery, underpinning many top-selling pharmaceuticals. Emerging developments in iron ligand-to-metal charge transfer (LMCT) catalysis have redefined fluoroalkylation chemistry by ...
Sara Fernández-García, Sara Cuadros, Irene Bosque, Jose C. Gonzalez-Gomez, Francisco Juliá-Hernández   +4 more
doaj   +2 more sources

Trifluoromethylation‐Induced Lactonization: A Novel Transformation of Unsaturated Carboxylic Acids

ChemistryOpen
Fluorinated drugs are highly important, and one of their common structural motifs is the trifluoromethyl group. As a result, there is an increasing demand for new or improved synthetic pathways toward trifluoromethylated compounds.
Attila M. Remete
doaj   +2 more sources

Photoorganocatalytic trifluoromethylation of (het)arenes in green conditions [PDF]

Beilstein Journal of Organic Chemistry
A sustainable photocatalytic protocol for the trifluoromethylation of (hetero)arenes is reported. The method operates under metal- and base-free conditions using an inexpensive and atom-efficient CF3 source, trifluoroacetic anhydride, in ethyl acetate as
Egor N. Boronin, Svetlana E. Kaurkina, Milena M. Svetlakova, Anton S. Bolshakov, Maxim V. Arsenyev, Vasilii F. Otvagin, Alexey Yu. Fedorov, Timothy Noël, Alexander V. Nyuchev   +8 more
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Advances in photocatalytic research on decarboxylative trifluoromethylation of trifluoroacetic acid and derivatives [PDF]

Frontiers in Chemistry
Trifluoromethylation stands as a pivotal technology in modern synthetic chemistry, playing an indispensable role in drug design, functional material development, and agrochemical innovation.
Fang-Fang Tan, Fang-Fang Tan, Zhan-Chao Li, Zhan-Chao Li   +3 more
doaj   +2 more sources

Advances in the Different Synthetic Routes of Fluorinated Hydrazines. [PDF]

Chem Rec
This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N‐fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
Kyrko D, Crousse B.
europepmc   +2 more sources

Heterogeneous Visible‐Light Photocatalysis in Continuous‐Flow: A Synergistic Strategy for Challenging Trifluoromethylation of α, α‐Diaryl Allylic Alcohols via 1,2‐aryl Migration

Advanced Science
Trifluoromethyl ketones are valuable scaffolds in drug discovery and material science, but their synthesis is often hindered by the need for prefunctionalized substrates, harsh oxidative conditions, and expensive trifluoromethylating reagents. To address
Peiwen Liu, Weiping Zhu, Xuhong Qian, Fang Zhao   +3 more
doaj   +2 more sources

Copper-Catalyzed Trifluoromethylation of Alkoxypyridine Derivatives

Molecules, 2020
The trifluoromethylation of aromatic and heteroaromatic cores has attracted considerable interest in recent years due to its pharmacological relevance.
Nandor Gyorfi, Emese Farkas, Norbert Nemet, Csaba Weber, Zoltan Novak, Andras Kotschy   +5 more
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Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system

Beilstein Journal of Organic Chemistry, 2021
A straightforward method that enables the formation of biologically attractive trifluoromethyl ketones from readily available methyl esters using the potent greenhouse gas fluoroform (HCF3, HFC-23) was developed.
Yamato Fujihira, Yumeng Liang, Makoto Ono, Kazuki Hirano, Takumi Kagawa, Norio Shibata   +5 more
doaj   +1 more source

Advances in [¹⁸F]Trifluoromethylation Chemistry for PET Imaging

Molecules, 2021
Positron emission tomography (PET) is a preclinical and clinical imaging technique extensively used to study and visualize biological and physiological processes in vivo.
Felix Francis, Frank Wuest
doaj   +1 more source

Cs2CO3-Initiated Trifluoro-Methylation of Chalcones and Ketones for Practical Synthesis of Trifluoromethylated Tertiary Silyl Ethers

Molecules, 2017
It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom ...
Cheng Dong, Xing-Feng Bai, Ji-Yuan Lv, Yu-Ming Cui, Jian Cao, Zhan-Jiang Zheng, Li-Wen Xu   +6 more
doaj   +1 more source