Results 1 to 10 of about 1,330 (177)

Catalytic trifluoromethylation of iodoarenes by use of 2-trifluoromethylated benzimidazoline as trifluoromethylating reagent [PDF]

Beilstein Journal of Organic Chemistry, 2020
The trifluoromethylation of iodoarenes was accomplished by use of a 2-trifluoromethylbenzimidazoline derivative as the trifluoromethylating reagent and a catalytic amount of Cu(I) in the presence of 2,2'-bipyridyl as the ligand.
Tatsuhiro Uchikura, Nanami Kamiyama, Taisuke Ishikawa, Takahiko Akiyama   +3 more
doaj   +3 more sources

Dual-role iron species in photoelectrocatalytic radical trifluoromethylation with trifluoroacetates [PDF]

Nature Communications
Trifluoromethylation remains a fundamental transformation in drug discovery, underpinning many top-selling pharmaceuticals. Emerging developments in iron ligand-to-metal charge transfer (LMCT) catalysis have redefined fluoroalkylation chemistry by ...
Sara Fernández-García, Sara Cuadros, Irene Bosque, Jose C. Gonzalez-Gomez, Francisco Juliá-Hernández   +4 more
doaj   +2 more sources

Advances in photocatalytic research on decarboxylative trifluoromethylation of trifluoroacetic acid and derivatives [PDF]

Frontiers in Chemistry
Trifluoromethylation stands as a pivotal technology in modern synthetic chemistry, playing an indispensable role in drug design, functional material development, and agrochemical innovation.
Fang-Fang Tan, Fang-Fang Tan, Zhan-Chao Li, Zhan-Chao Li   +3 more
doaj   +2 more sources

Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent [PDF]

Beilstein Journal of Organic Chemistry, 2013
An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been developed. The reactions proceeded smoothly to give trifluoromethylated alkenes in good to excellent yields.
Xiao-Ping Wang, Jin-Hong Lin, Cheng-Pan Zhang, Ji-Chang Xiao, Xing Zheng   +4 more
doaj   +3 more sources

Photoorganocatalytic trifluoromethylation of (het)arenes in green conditions [PDF]

Beilstein Journal of Organic Chemistry
A sustainable photocatalytic protocol for the trifluoromethylation of (hetero)arenes is reported. The method operates under metal- and base-free conditions using an inexpensive and atom-efficient CF3 source, trifluoroacetic anhydride, in ethyl acetate as
Egor N. Boronin, Svetlana E. Kaurkina, Milena M. Svetlakova, Anton S. Bolshakov, Maxim V. Arsenyev, Vasilii F. Otvagin, Alexey Yu. Fedorov, Timothy Noël, Alexander V. Nyuchev   +8 more
doaj   +2 more sources

Copper-Catalyzed Trifluoromethylation of Alkoxypyridine Derivatives

Molecules, 2020
The trifluoromethylation of aromatic and heteroaromatic cores has attracted considerable interest in recent years due to its pharmacological relevance.
Nandor Gyorfi, Emese Farkas, Norbert Nemet, Csaba Weber, Zoltan Novak, Andras Kotschy   +5 more
doaj   +1 more source

Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system

Beilstein Journal of Organic Chemistry, 2021
A straightforward method that enables the formation of biologically attractive trifluoromethyl ketones from readily available methyl esters using the potent greenhouse gas fluoroform (HCF3, HFC-23) was developed.
Yamato Fujihira, Yumeng Liang, Makoto Ono, Kazuki Hirano, Takumi Kagawa, Norio Shibata   +5 more
doaj   +1 more source

Synthesis of Trifluoromethylated Monoterpene Amino Alcohols

Molecules, 2022
For the first time, monoterpene trifluoromethylated β-hydroxy-benzyl-O-oximes were synthesized in 81–95% yields by nucleophilic addition of the Ruppert–Prakash reagent (TMSCF3) to the corresponding β-keto-benzyl-O-oximes based on (+)-nopinone ...
Polina A. Petrova, Denis V. Sudarikov, Larisa L. Frolova, Roman V. Rumyantcev, Svetlana A. Rubtsova, Aleksandr V. Kutchin   +5 more
doaj   +1 more source

Activation of SF₅CF₃ by the N-Heterocyclic Carbene SIMes

Molecules, 2023
The greenhouse gas SF5CF3 was photochemically activated with SIMes (1,3-Bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene) to give 1,3-dimesityl-2,2-difluoroimidazolidine (SIMesF2), and 1,3-dimesitylimidazolidine-2-sulfide, as well as the ...
Domenique Herbstritt, Pooja Tomar, Thomas Braun   +2 more
doaj   +1 more source

Photoredox Catalytic Trifluoromethylation and Perfluoroalkylation of Arenes Using Trifluoroacetic and Related Carboxylic Acids

Cell Reports Physical Science, 2020
Summary: Trifluoroacetic acid (TFA) is among the most attractive trifluoromethylation reagents with respect to its low prices, ease of handling, and availability in large quantities.
Dehang Yin, Dengquan Su, Jian Jin
doaj   +1 more source