Trifluoromethylation‐Induced Lactonization: A Novel Transformation of Unsaturated Carboxylic Acids [PDF]
ChemistryOpenFluorinated drugs are highly important, and one of their common structural motifs is the trifluoromethyl group. As a result, there is an increasing demand for new or improved synthetic pathways toward trifluoromethylated compounds.
Attila M. Remete
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Heterogeneous Visible‐Light Photocatalysis in Continuous‐Flow: A Synergistic Strategy for Challenging Trifluoromethylation of α, α‐Diaryl Allylic Alcohols via 1,2‐aryl Migration [PDF]
Advanced ScienceTrifluoromethyl ketones are valuable scaffolds in drug discovery and material science, but their synthesis is often hindered by the need for prefunctionalized substrates, harsh oxidative conditions, and expensive trifluoromethylating reagents. To address
Peiwen Liu +3 more
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Catalytic trifluoromethylation of iodoarenes by use of 2-trifluoromethylated benzimidazoline as trifluoromethylating reagent [PDF]
Beilstein Journal of Organic Chemistry, 2020 The trifluoromethylation of iodoarenes was accomplished by use of a 2-trifluoromethylbenzimidazoline derivative as the trifluoromethylating reagent and a catalytic amount of Cu(I) in the presence of 2,2'-bipyridyl as the ligand.
Tatsuhiro Uchikura +3 more
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Copper-Catalyzed Trifluoromethylation of Alkoxypyridine Derivatives
Molecules, 2020 The trifluoromethylation of aromatic and heteroaromatic cores has attracted considerable interest in recent years due to its pharmacological relevance.
Nandor Gyorfi +5 more
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Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent [PDF]
Beilstein Journal of Organic Chemistry, 2013 An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been developed. The reactions proceeded smoothly to give trifluoromethylated alkenes in good to excellent yields.
Xiao-Ping Wang +4 more
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Dual-role iron species in photoelectrocatalytic radical trifluoromethylation with trifluoroacetates [PDF]
Nature CommunicationsTrifluoromethylation remains a fundamental transformation in drug discovery, underpinning many top-selling pharmaceuticals. Emerging developments in iron ligand-to-metal charge transfer (LMCT) catalysis have redefined fluoroalkylation chemistry by ...
Sara Fernández-García +4 more
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Photoorganocatalytic trifluoromethylation of (het)arenes in green conditions [PDF]
Beilstein Journal of Organic ChemistryA sustainable photocatalytic protocol for the trifluoromethylation of (hetero)arenes is reported. The method operates under metal- and base-free conditions using an inexpensive and atom-efficient CF3 source, trifluoroacetic anhydride, in ethyl acetate as
Egor N. Boronin +8 more
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Advances in photocatalytic research on decarboxylative trifluoromethylation of trifluoroacetic acid and derivatives [PDF]
Frontiers in ChemistryTrifluoromethylation stands as a pivotal technology in modern synthetic chemistry, playing an indispensable role in drug design, functional material development, and agrochemical innovation.
Fang-Fang Tan +3 more
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Beilstein Journal of Organic Chemistry, 2021 A straightforward method that enables the formation of biologically attractive trifluoromethyl ketones from readily available methyl esters using the potent greenhouse gas fluoroform (HCF3, HFC-23) was developed.
Yamato Fujihira +5 more
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Advances in [18F]Trifluoromethylation Chemistry for PET Imaging
Molecules, 2021 Positron emission tomography (PET) is a preclinical and clinical imaging technique extensively used to study and visualize biological and physiological processes in vivo.
Felix Francis, Frank Wuest
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