Results 21 to 30 of about 3,603 (218)

Regioselective C3-H Trifluoromethylation of 2H-Indazole Under Transition-Metal-Free Photoredox Catalysis [PDF]

, 2019
Here we report a visible-light-promoted metal-free regioselective C3-H trifluoromehtylation reaction that proceeds via radical mechanism and which supported by control experiments.
Sharada, Duddu. S, Arumugavel, Murugan, Nagaraj, Sabarinathan, Venkata Nagarjuna, Babu   +3 more
core   +1 more source

Visible-light-induced trifluoromethylation of allylic alcohols

, 2021
An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent.
Zeng, Wubing, Loh, Teck-Peng, Geng, Zhishuai, Xie, Peizhong, Wang, Lin, Li, Bowen   +5 more
core   +1 more source

Late-Stage Trifluoromethylation [PDF]

, 2016
This thesis is concerned with the development of methodology for late-stage trifluoromethylation of complex molecules. Chapter 1 introduces the concept of late-stage trifluoromethylations and details the effect that substitution of a CF3 group can have ...
Verhoog, Stefan, Stefan Verhoog
core   +1 more source

Dye-incorporated coordination polymers for direct photocatalytic trifluoromethylation of aromatics at metabolically susceptible positions

Nature Communications, 2018
Direct trifluoromethylation of unactivated aromatic rings at metabolically susceptible positions is highly desirable in pharmaceutical fields.
Tiexin Zhang, Xiangyang Guo, Yusheng Shi, Cheng He, Chunying Duan   +4 more
doaj   +1 more source

Photoredox Catalytic Trifluoromethylation and Perfluoroalkylation of Arenes Using Trifluoroacetic and Related Carboxylic Acids

Cell Reports Physical Science, 2020
Summary: Trifluoroacetic acid (TFA) is among the most attractive trifluoromethylation reagents with respect to its low prices, ease of handling, and availability in large quantities.
Dehang Yin, Dengquan Su, Jian Jin
doaj   +1 more source

3-(4-Fluorophenyl)-1-(1-(4-fluorophenyl)-3,3,3-trifluoroprop-1-en-1-yl)-5-fluoro-1H-pyrazole

Molbank, 2023
In this work, the title compound was synthesized via the visible-light-induced radical denitrogenative trifluoromethylation of the corresponding vinyl azide followed by Cs2CO3-mediated defluorinative cyclization of the resultant azine.
Stanislav A. Paveliev, Alexander O. Ustyuzhanin, Igor B. Krylov, Alexander O. Terent’ev   +3 more
doaj   +1 more source

Reduction of SF5CF3via iridium catalysis: radical trifluoromethylation of aromatics [PDF]

, 2023
The greenhouse gas SF5CF3 acts as CF3 source for the photocatalytic trifluoromethylation of arenes on using [Ir(dtbbpy)(ppy)2]PF6 (4,4′-di-tert-butyl-2,2′-dipyridyl, ppy = 2-phenylpyridine) as catalyst. The trifluoromethylation of C6D6 in the presence of
Braun, Thomas, Herbstritt, Domenique
core   +1 more source

Direct C–H trifluoromethylation of di- and trisubstituted alkenes by photoredox catalysis

Beilstein Journal of Organic Chemistry, 2014
Background: Trifluoromethylated alkene scaffolds are known as useful structural motifs in pharmaceuticals and agrochemicals as well as functional organic materials.
Ren Tomita, Yusuke Yasu, Takashi Koike, Munetaka Akita   +3 more
doaj   +1 more source

Visible Light Promotes Cascade Trifluoromethylation/Cyclization, Leading to Trifluoromethylated Polycyclic Quinazolinones, Benzimidazoles and Indoles

Molecules, 2022
Efficient visible-light-induced radical cascade trifluoromethylation/cyclization of inactivated alkenes with CF3Br, which is a nonhygroscopic, noncorrosive, cheap and industrially abundant chemical, was developed in this work, producing trifluoromethyl ...
Ransong Ma, Yuanyuan Ren, Zhoubin Deng, Ke-Hu Wang, Junjiao Wang, Danfeng Huang, Yulai Hu, Xiaobo Lv   +7 more
doaj   +1 more source

Harnessing the Reactivity of Sulfinate Salts With Cystine: An Umpolung Approach to Residue‐Specific Peptide Modification

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
While cysteine is widely employed as a nucleophilic handle for peptide modification, the electrophilicity of the oxidized form, cystine, is rarely exploited. This study describes a mild, photochemical coupling of sulfinate salts with peptide disulfides.
Joshua M. Hammond, Esteban Suárez‐Picado, Lena von Sydow, Hanna Bruss, Laurent Knerr, Magnus Johansson, Anaïs Noisier, Lara R. Malins   +7 more
wiley   +2 more sources