Results 11 to 20 of about 1,340 (176)
Catalytic trifluoromethylation of iodoarenes by use of 2-trifluoromethylated benzimidazoline as trifluoromethylating reagent [PDF]
Beilstein Journal of Organic Chemistry, 2020 The trifluoromethylation of iodoarenes was accomplished by use of a 2-trifluoromethylbenzimidazoline derivative as the trifluoromethylating reagent and a catalytic amount of Cu(I) in the presence of 2,2'-bipyridyl as the ligand.
Tatsuhiro Uchikura +3 more
doaj +3 more sources
Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent [PDF]
Beilstein Journal of Organic Chemistry, 2013 An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been developed. The reactions proceeded smoothly to give trifluoromethylated alkenes in good to excellent yields.
Xiao-Ping Wang +4 more
doaj +3 more sources
Nature Communications, 2018 Direct trifluoromethylation of unactivated aromatic rings at metabolically susceptible positions is highly desirable in pharmaceutical fields.
Tiexin Zhang +4 more
doaj +1 more source
Cell Reports Physical Science, 2020 Summary: Trifluoroacetic acid (TFA) is among the most attractive trifluoromethylation reagents with respect to its low prices, ease of handling, and availability in large quantities.
Dehang Yin, Dengquan Su, Jian Jin
doaj +1 more source
3-(4-Fluorophenyl)-1-(1-(4-fluorophenyl)-3,3,3-trifluoroprop-1-en-1-yl)-5-fluoro-1H-pyrazole
Molbank, 2023 In this work, the title compound was synthesized via the visible-light-induced radical denitrogenative trifluoromethylation of the corresponding vinyl azide followed by Cs2CO3-mediated defluorinative cyclization of the resultant azine.
Stanislav A. Paveliev +3 more
doaj +1 more source
Progress in copper-catalyzed trifluoromethylation
Beilstein Journal of Organic Chemistry, 2018 The introduction of trifluoromethyl groups into organic molecules has attracted great attention in the past five years. In this review, we describe the recent efforts in the development of trifluoromethylation via copper catalysis using nucleophilic ...
Guan-bao Li +3 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.A robust and efficient method to access diversely functionalized fluorinated piperidines was developed. The approach features the hydrogenation of polysubstituted pyridines bearing CF3, CF2H, and CF2CO2Et substituents using an inexpensive, readily available heterogeneous Pd/C catalyst under air‐ and moisture‐tolerant conditions, offering an appealing ...
Thibaud Charvillat +7 more
wiley +2 more sources
Direct C–H trifluoromethylation of di- and trisubstituted alkenes by photoredox catalysis
Beilstein Journal of Organic Chemistry, 2014 Background: Trifluoromethylated alkene scaffolds are known as useful structural motifs in pharmaceuticals and agrochemicals as well as functional organic materials.
Ren Tomita +3 more
doaj +1 more source
Molecules, 2022 Efficient visible-light-induced radical cascade trifluoromethylation/cyclization of inactivated alkenes with CF3Br, which is a nonhygroscopic, noncorrosive, cheap and industrially abundant chemical, was developed in this work, producing trifluoromethyl ...
Ransong Ma +7 more
doaj +1 more source
Trifluoromethylation of graphene
APL Materials, 2014 We demonstrate trifluoromethylation of graphene by copper-catalyzed free radical reaction. The covalent addition of CF3 to graphene, which changes the carbon atom hybridization from sp2 to sp3, and modifies graphene in a homogeneous and nondestructive ...
Lin Zhou +7 more
doaj +1 more source