Progress in copper-catalyzed trifluoromethylation
Beilstein Journal of Organic Chemistry, 2018 The introduction of trifluoromethyl groups into organic molecules has attracted great attention in the past five years. In this review, we describe the recent efforts in the development of trifluoromethylation via copper catalysis using nucleophilic ...
Guan-bao Li +3 more
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Trifluoromethylation of graphene
APL Materials, 2014 We demonstrate trifluoromethylation of graphene by copper-catalyzed free radical reaction. The covalent addition of CF3 to graphene, which changes the carbon atom hybridization from sp2 to sp3, and modifies graphene in a homogeneous and nondestructive ...
Lin Zhou +7 more
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Photocatalytic Activation of Fluoroform for Radical Trifluoromethylation. [PDF]
J Am Chem SocFluoroform is an ideal trifluoromethyl source in synthetic chemistry due to its low cost, low toxicity, and high potential for greenhouse-gas valorization.
Zhou S +9 more
europepmc +2 more sources
3-Position-Selective C–H Trifluoromethylation of Pyridine Rings Based on Nucleophilic Activation [PDF]
, 2022 The first example of the 3-position-selective C(sp2)–H trifluoromethylation of pyridine rings was established. 3-Position-selective trifluoromethylation was achieved by the nucleophilic activation of pyridine and quinoline derivatives through ...
Yoichiro, Kuninobu +2 more
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Redox-Neutral Decarboxylative and Desulfonylative C(sp3) Trifluoromethylation: Method Development and Mechanistic Inquiry [PDF]
, 2023 Sodium triflinate (CF3SO2Na) is an inexpensive bench stable radical CF3 source that is often activated by external oxidants such as peroxides. However, despite the commercial accessibility of CF3SO2Na, the salt has never been applied to decarboxylative ...
Chris, Seong, Courtney, Roberts
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Regioselective C–H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins [PDF]
, 2021 A regioselective radical C–H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C–H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale ...
Jizhou, Song +5 more
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Site-specific Deaminative Trifluoromethylation of Aliphatic Primary Amines [PDF]
, 2023 The introduction of trifluoromethyl groups into organic molecules is of paramount importance in modern synthetic chemistry and medicinal chemistry. While methods for constructing C(sp2)-CF3 bonds have been well established, the advancement of practical ...
Yin , Li +4 more
core +2 more sources
Commercial-Scale Visible-light Trifluoromethylation of 2-Chlorothiophenol using CF3I gas. [PDF]
, 2021 Despite the growth of photoredox methods in academia, application of photoredox at scale in the pharmaceutical and fine chemical industries has been slow.
Ping-zhong, Huang +15 more
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Rapid Biomolecular Trifluoromethylation Using Cationic Aromatic Sulfonate Esters as Visible Light-Triggered Radical Photocages [PDF]
, 2023 Described here is a photo-decaging approach to radical trifluoromethylation of biomolecules. This was accomplished by designing a quinolinium sulfonate ester that, upon absorption of visible light, achieves decaging via photolysis of the sulfonate ester
Michael, Taylor, Nicholas, Kuehl
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Molecules, 2017 It was found that 1,2-trifluoromethylation reactions of ketones, enones, and aldehydes were easily accomplished using the Prakash reagent in the presence of catalytic amounts of cesium carbonate, which represents an experimentally convenient, atom ...
Cheng Dong +6 more
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