Results 41 to 50 of about 3,603 (218)

Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines

Organic & Biomolecular Chemistry, 2015
A ligand and base free copper catalyzed method has been developed for the construction of trifluoromethylated benzoxazines by using Umemoto's reagent.
Sadhan Jana, Athira Ashokan, Shailesh Kumar, Ajay Verma, Sangit Kumar   +4 more
openaire   +3 more sources

Nucleophilic conjugate trifluoromethylation of chromones and activated alkenes under the action of Ruppert’s reagent

Chimica Techno Acta, 2017
This review summarizes data on the reactions of chromones and activated alkenes with trimethyl(trifluoromethyl)silane (Ruppert’s reagent), which occures as a nucleophilic 1,4-trifluoromethylation with high regioselectivity and good yields.
V. Ya. Sosnovskikh, G.-V. Roshentaler
doaj   +1 more source

MurNAc‐Based Electrophilic Inhibitors of O‐Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation

Chemistry – A European Journal, EarlyView.
A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley   +1 more source

Visible-Light-Induced Photocatalyst-Free Radical Trifluoromethylation

, 2022
An attractive, versatile, and operationally simple, visible-light-induced, transition-metal-free, photocatalyst-free, and oxidant-free trifluoromethylation has been demonstrated.
Xin Liang (442470), Kaikai Niu (11776915), Weihua Zhang (44940), Yufei Li (433737), Jun Gu (89637), Qing Xia (114230), Qingmin Wang (106260), Fang Liu (13271)   +7 more
core   +1 more source

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source

Catalysis for fluorination and trifluoromethylation [PDF]

Nature, 2011
Recent advances in catalysis have made the incorporation of fluorine into complex organic molecules easier than ever before, but selective, general and practical fluorination reactions remain sought after. Fluorination of molecules often imparts desirable properties, such as metabolic and thermal stability, and fluorinated molecules are therefore ...
Takeru, Furuya, Adam S, Kamlet, Tobias, Ritter   +2 more
openaire   +2 more sources

Synthesis and trifluoromethylation of allylsilanes [PDF]

, 2013
The first part of this thesis presents a novel approach for synthesising enantioenriched cyclic allylsilanes via asymmetric ring-closing metathesis (ARCM).
Galicia Lopez, Oscar, Gouverneur, Veronique   +1 more
core   +2 more sources

Nucleophilic Trifluoromethoxylation of Acyl Chlorides: A Direct Route to Trifluoromethyl Esters

Advanced Synthesis &Catalysis, Volume 368, Issue 18, 19 September 2026.
A new method for the synthesis of the underexplored trifluoromethyl carboxylic esters using acyl chlorides as readily available feedstocks and in situ‐generated AgOCF3 from silver fluoride and the trifluoromethyl para‐toluenesulfonate has been designed. The reaction works on a large variety of aromatic and aliphatic acyl chlorides, while minimizing the
Xavier Bertrand, Vincent Herrera, Olga García Mancheño, Tatiana Besset   +3 more
wiley   +1 more source

Trifluoromethylation of Secondary Nitroalkanes [PDF]

Organic Letters, 2017
Using a commercially available Umemoto's reagent, the metal-free trifluoromethylation of nitroalkanes is now possible. This method provides a general, high-yielding synthesis of α-(trifluoromethyl)nitroalkanes. The quaternary α-(trifluoromethyl)nitroalkanes obtained from this transformation can be elaborated to a variety of complex nitrogen-containing ...
Amber A. S. Gietter-Burch, Vijayarajan Devannah, Donald A. Watson   +2 more
openaire   +2 more sources

Synthesis of Trifluoromethylated Monoterpene Amino Alcohols

Molecules, 2022
For the first time, monoterpene trifluoromethylated β-hydroxy-benzyl-O-oximes were synthesized in 81–95% yields by nucleophilic addition of the Ruppert–Prakash reagent (TMSCF3) to the corresponding β-keto-benzyl-O-oximes based on (+)-nopinone ...
Polina A. Petrova, Denis V. Sudarikov, Larisa L. Frolova, Roman V. Rumyantcev, Svetlana A. Rubtsova, Aleksandr V. Kutchin   +5 more
doaj   +1 more source