Results 51 to 60 of about 1,340 (176)

C4 Functionalization of the Isoquinoline Core via Oxidative Radical Substitution

ChemistrySelect, Volume 11, Issue 21, 4 June 2026.
The isoquinoline ring can be easily functionalized at C‐4 through a radical‐oxidative substitution process. The resulting products can be readily cyclized under basic conditions, facilitating the construction of pyranones fused to the isoquinoline scaffold. ABSTRACTIn this work, we report a straightforward synthetic procedure that enables the selective
Oscar Coral, Cesar A. Mujica‐Martinez, Alfredo Vázquez   +2 more
wiley   +1 more source

Comparative profiling of well-defined copper reagents and precursors for the trifluoromethylation of aryl iodides

Beilstein Journal of Organic Chemistry, 2017
A number of copper reagents were compared for their effectiveness in trifluoromethylating 4-iodobiphenyl, 4-iodotoluene, and 2-iodotoluene. Yields over time were plotted in order to refine our understanding of each reagent performance, identify any ...
Peter T. Kaplan, Jessica A. Lloyd, Mason T. Chin, David A. Vicic   +3 more
doaj   +1 more source

Metal‐Catalyzed C(sp2)–H Bond Functionalization of Indolinone‐ and Indanone‐Type Chemical Platforms En Route Toward Late‐Stage Functionalization

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
An in‐depth survey dealing with the aromatic C—H bond functionalization of biologically‐relevant scaffolds featuring the indolinone and indanone core is discussed as they are unique aromatic scaffolds that are 1,2‐doubly fused with small five‐membered rings.
Vanessa Delahaye, Sylvie Dérien, Mathieu Achard, Rafael Gramage‐Doria   +3 more
wiley   +1 more source

Gold trifluoromethyl complexes

Dalton Transactions, 2015
This Perspective reviews the synthesis, structure, reactivity and applications of gold trifluoromethyl complexes. The recently reported reactions of gold(iii) trifluoromethyl complexes with potential application in synthesis are discussed.
Juan, Gil-Rubio, José, Vicente
openaire   +3 more sources

Introducing Weakly Ligated Tris(trifluoromethyl)copper(III)

ChemistryEurope
Tris(trifluoromethyl)copper(III), Cu(CF3)3, was prepared for the first time and fully characterized in the form of weakly coordinated highly reactive solvent neutral adducts (DMF)2Cu(CF3)3 and (MeCN)Cu(CF3)3.
Dr. Vladimir Motornov, Martin Procházka, Nora Alpuente, Dr. Pedro Salvador, Prof. Petr Slavíček, Dr. Blanka Klepetářová, Prof. Xavi Ribas, Dr. Petr Beier   +7 more
doaj   +1 more source

Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions

Frontiers in Chemistry, 2019
A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including
Xiaolin Shi, Xiaolin Shi, Xiaolin Shi, Xiaowei Li, Xiaowei Li, Xiaowei Li, Xiangqian Li, Dayong Shi   +7 more
doaj   +1 more source

Determining the predominant tautomeric structure of iodine-based group-transfer reagents by 17O NMR spectroscopy

Beilstein Journal of Organic Chemistry, 2018
Cyclic benziodoxole systems have become a premier scaffold for the design of electrophilic transfer reagents. A particularly intriguing aspect is the fundamental II–IIII tautomerism about the hypervalent bond, which has led in certain cases to a ...
Nico Santschi, Cody Ross Pitts, Benson J. Jelier, René Verel   +3 more
doaj   +1 more source

Trifluoroethoxy-Coated Phthalocyanine Catalyzes Perfluoroalkylation of Alkenes under Visible-Light Irradiation

Molecules, 2017
We disclose herein the perfluoroalkylation of alkenes catalyzed by trifluoroethoxy-coated zinc phthalocyanine under irradiation of visible light. Perfluoroalkyl iodides were nicely incorporated into unsaturated substrates, including alkyne, to provide ...
Kohei Matsuzaki, Tomoya Hiromura, Hideki Amii, Norio Shibata   +3 more
doaj   +1 more source

Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR

Molecules, 2010
A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation.
Lihe Zhang, Liangren Zhang, Min Dong, Jian Liu, Kehui Zhang, Zhenjun Yang, Xiangchen Huang   +6 more
doaj   +1 more source

Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

Beilstein Journal of Organic Chemistry, 2013
In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research.
Grégory Landelle, Armen Panossian, Sergiy Pazenok, Jean-Pierre Vors, Frédéric R. Leroux   +4 more
doaj   +1 more source