Results 51 to 60 of about 1,330 (177)

The C3-H Bond Functionalization of Quinoxalin-2(1H)-Ones With Hypervalent Iodine(III) Reagents

Frontiers in Chemistry, 2020
The modification of quinoxalin-2(1H)-ones via direct C-H bond functionalization has begun to receive widespread attention, due to quinoxalin-2(1H)-one derivatives' various biological activities and pharmaceutical properties. This mini review concentrates
Yushi Tan, Jiabo Wang, Hong-Yu Zhang, Yuecheng Zhang, Jiquan Zhao   +4 more
doaj   +1 more source

Trifluoromethyl-substituted tetrathiafulvalenes [PDF]

Beilstein Journal of Organic Chemistry, 2015
A series of tetrathiafulvalenes functionalized with one or two trifluoromethyl electron-withdrawing groups (EWG) is obtained by phosphite coupling involving CF3-substituted 1,3-dithiole-2-one derivatives. The relative effects of the EWG such as CF3, CO2Me and CN on the TTF core were investigated from a combination of structural, electrochemical ...
Jeannin, Olivier, Barrière, Frédéric, Fourmigué, Marc   +2 more
openaire   +4 more sources

Metal‐Catalyzed C(sp2)–H Bond Functionalization of Indolinone‐ and Indanone‐Type Chemical Platforms En Route Toward Late‐Stage Functionalization

Advanced Synthesis &Catalysis, Volume 368, Issue 8, 15 April 2026.
An in‐depth survey dealing with the aromatic C—H bond functionalization of biologically‐relevant scaffolds featuring the indolinone and indanone core is discussed as they are unique aromatic scaffolds that are 1,2‐doubly fused with small five‐membered rings.
Vanessa Delahaye, Sylvie Dérien, Mathieu Achard, Rafael Gramage‐Doria   +3 more
wiley   +1 more source

Gold trifluoromethyl complexes

Dalton Transactions, 2015
This Perspective reviews the synthesis, structure, reactivity and applications of gold trifluoromethyl complexes. The recently reported reactions of gold(iii) trifluoromethyl complexes with potential application in synthesis are discussed.
Juan, Gil-Rubio, José, Vicente
openaire   +3 more sources

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

ChemistryOpen, Volume 15, Issue 4, April 2026.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

Nucleophilic fluoroalkylation/cyclization route to fluorinated phthalides

Beilstein Journal of Organic Chemistry, 2018
Discribed in this article is a versatile and practical method for the synthesis of C3-perfluoroalkyl-substituted phthalides in a one-pot manner. Upon treatment of KF or triethylamine, 2-cyanobenzaldehyde reacted with (perfluoroalkyl)trimethylsilanes via ...
Masanori Inaba, Tatsuya Sakai, Shun Shinada, Tsuyuka Sugiishi, Yuta Nishina, Norio Shibata, Hideki Amii   +6 more
doaj   +1 more source

A General Group Testing Strategy for Discovering Chemical Cooperativity

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
A combinatorial design theory‐based group testing strategy coupled with luminescence screening to uncover cooperative interactions in a large combinatorial space. Iterative deconvolution identifies reactive molecular pairs and enables the discovery of trifluoromethylthiolation (SCF3) reagents.
Philipp M. Pflüger, Felix Katzenburg, Frederik Sandfort, Michael Teders, Adrián Gómez‐Suárez, Eric A. Standley, Matthew N. Hopkinson, Constantin G. Daniliuc, Andreas Heuer, Frank Glorius   +9 more
wiley   +1 more source

Cu-catalyzed trifluoromethylation of aryl iodides with trifluoromethylzinc reagent prepared in situ from trifluoromethyl iodide

Beilstein Journal of Organic Chemistry, 2013
The trifluoromethylation of aryl iodides catalyzed by copper(I) salt with trifluoromethylzinc reagent prepared in situ from trifluoromethyl iodide and Zn dust was accomplished.
Yuzo Nakamura, Motohiro Fujiu, Tatsuya Murase, Yoshimitsu Itoh, Hiroki Serizawa, Kohsuke Aikawa, Koichi Mikami   +6 more
doaj   +1 more source

Comparative profiling of well-defined copper reagents and precursors for the trifluoromethylation of aryl iodides

Beilstein Journal of Organic Chemistry, 2017
A number of copper reagents were compared for their effectiveness in trifluoromethylating 4-iodobiphenyl, 4-iodotoluene, and 2-iodotoluene. Yields over time were plotted in order to refine our understanding of each reagent performance, identify any ...
Peter T. Kaplan, Jessica A. Lloyd, Mason T. Chin, David A. Vicic   +3 more
doaj   +1 more source

Ligand- and Additive-Free 2-Position-Selective Trifluoromethylation of Heteroarenes Under Ambient Conditions

Frontiers in Chemistry, 2019
A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including
Xiaolin Shi, Xiaolin Shi, Xiaolin Shi, Xiaowei Li, Xiaowei Li, Xiaowei Li, Xiangqian Li, Dayong Shi   +7 more
doaj   +1 more source