Results 61 to 70 of about 1,330 (177)

Determining the predominant tautomeric structure of iodine-based group-transfer reagents by 17O NMR spectroscopy

Beilstein Journal of Organic Chemistry, 2018
Cyclic benziodoxole systems have become a premier scaffold for the design of electrophilic transfer reagents. A particularly intriguing aspect is the fundamental II–IIII tautomerism about the hypervalent bond, which has led in certain cases to a ...
Nico Santschi, Cody Ross Pitts, Benson J. Jelier, René Verel   +3 more
doaj   +1 more source

Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

Beilstein Journal of Organic Chemistry, 2013
In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research.
Grégory Landelle, Armen Panossian, Sergiy Pazenok, Jean-Pierre Vors, Frédéric R. Leroux   +4 more
doaj   +1 more source

Photocatalytic fluoroalkylation by ligand-to-metal charge transfer

Frontiers in Chemistry
Trifluoromethyl (CF3) and other fluoroalkyl groups are of great significance in the fields of pharmaceutical chemistry and agricultural chemicals. Fluoroalkyl acids, especially trifluoroacetic acid (TFA) is considered the most ideal fluoroalkylation ...
Jingyi Liu, Zhenwei Cui, Jingjing Bi, Xing He, Qingjie Ding, Hong Zhu, Chunhua Ma   +6 more
doaj   +1 more source

Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective

Beilstein Journal of Organic Chemistry, 2010
Since the discovery by Yagupolskii and co-workers that S-trifluoromethyl diarylsulfonium salts are effective for the trifluoromethylation of thiophenolates, the design and synthesis of electrophilic trifluoromethylating reagents have been extensively ...
Norio Shibata, Andrej Matsnev, Dominique Cahard   +2 more
doaj   +1 more source

Copper-catalyzed remote C(sp 3)–H azidation and oxidative trifluoromethylation of benzohydrazides

Nature Communications, 2019
Functionalization of carbon radicals formed via 1,5-hydrogen atom transfer of amidyl radicals is an underdeveloped protocol for remote C–H functionalization.
Xu Bao, Qian Wang, Jieping Zhu
doaj   +1 more source

THE RADICAL C-H FUNCTIONALIZATION OF NATURAL COMPOUNDS

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2019
Selective functionalization of complex scaffolds is a promising approach to increase the pharmacological profiles of natural products and their derivatives.
Vladilena GÎRBU
doaj  

1,6-Nucleophilic Di- and Trifluoromethylation of para-Quinone Methides with Me₃SiCF₂H/Me₃SiCF₃ Facilitated by CsF/18-Crown-6

Molecules
The direct 1,6-nucleophilic difluoromethylation, trifluoromethylation, and difluoroalkylation of para-quinone methides (p-QMs) with Me3SiRf (Rf = CF2H, CF3, CF2CF3, CF2COOEt, and CF2SPh) under mild conditions are described. Although Me3SiCF2H shows lower
Dingben Chen, Ling Huang, Mingyu Liang, Xiaojing Chen, Dongdong Cao, Pan Xiao, Chuanfa Ni, Jinbo Hu   +7 more
doaj   +1 more source

1,2-Oxidative Trifluoromethylation of Olefin with Ag(O₂CCF₂SO₂F) and O₂: Synthesis of α-Trifluoromethyl Ketones

Molecules
A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O2CCF2SO2F) as a trifluoromethyl source is described with O2 as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones.
Shengxue Zhang, Wangchuan Xiao, Jingjing Wu, Fanhong Wu, Houjin Huang, Xiaoyu Ma, Yafei Shi, Chao Liu   +7 more
doaj   +1 more source

Visible-light-induced radical cascade cyclization: a catalyst-free synthetic approach to trifluoromethylated heterocycles

Beilstein Journal of Organic Chemistry
A visible-light-promoted research protocol for constructing dihydropyrido[1,2-a]indolone skeletons is herein described proceeding through a cascade cyclization mediated by trifluoromethyl radicals.
Chuan Yang, Wei Shi, Jian Tian, Lin Guo, Yating Zhao, Wujiong Xia   +5 more
doaj   +1 more source

Langlois Reagent: An Efficient Trifluoromethylation Reagent

SynOpen, 2023
K. Anusha, Megha Mahesh, Shikha Shikha, T. M. Rangarajan, Sharda Pasricha   +4 more
doaj   +1 more source